Datelliptium chloride

Cat. No.: HY-U00337 Purity: 99.63%: FAQs
Data Sheet SDS COA Handling Instructions

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Datelliptium chloride is a DNA-intercalating agent derived from ellipticine, with anti-tumor activities.

For research use only. We do not sell to patients.

Datelliptium chloride Chemical Structure

CAS No. : 105118-14-7

Size	Price	Stock	Quantity
1 mg	USD 680	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1450	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 2350	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 4600	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Other Forms of Datelliptium chloride:

Datelliptium chloride hydrochloride Get quote

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Biological Activity
Protocol
Purity & Documentation
References
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Description

Datelliptium chloride is a DNA-intercalating agent derived from ellipticine, with anti-tumor activities.

In Vitro

Datelliptium (100 μM) shows significantly cytotoxic effects after 2 hr of treatment in suspension and primary cultures of rat hepatocytes. Datelliptium mobilizes glycogen in both rat systems in vitro concentration dependently. The half-maximal effect is 14.3 μM in isolated hepatocytes, whereas in cultured rat hepatocytes it is 5.9 μM. Datelliptium also leads to a concentration-dependent decrease in gluconeogenesis from lactate in cells^[1]. Datelliptium acetate is selectively cytotoxic for solid tumors over leukemia L1210. Human tumors H-125 and HCT-116 demonstrates less sensitivity to datelliptium acetate^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Upon intravenous administration, datelliptium acetate shows potent inhibitory activities in vivo against a variety of murine solid tumors. Datelliptium acetate is highly active against early-stage colon #38 with highest non-toxic dose (HNTD) of 170 mg/kg TD, and weight loss of 10%, T/C of 0%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

397.94

Formula

C₂₃H₂₈ClN₃O

CAS No.

105118-14-7

Appearance

Solid

Color

Pink to red

SMILES

CC1=C2C(NC3=C2C=C(O)C=C3)=C(C)C4=CC=[N+](CCN(CC)CC)C=C41.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 41.67 mg/mL (104.71 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5129 mL	12.5647 mL	25.1294 mL
5 mM	0.5026 mL	2.5129 mL	5.0259 mL
10 mM	0.2513 mL	1.2565 mL	2.5129 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.63%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (248 KB) HNMR (227 KB) LCMS (119 KB)

Handling Instructions (2659 KB)

References

[1]. Donato MT, et al. Toxicity of the antitumoral drug datelliptium in hepatic cells: Use of models in vitro for the prediction of toxicity in vivo. Toxicol In Vitro. 1992 Jul;6(4):295-302. [Content Brief]

[2]. Mucci-LoRusso P, et al. Activity of datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice. Invest New Drugs. 1990 Aug;8(3):253-61. [Content Brief]

Cell Assay
^[1]

Cytotoxicity is estimated after short-term exposure (2 hr) to datelliptium using suspended and cultured rat hepatocytes. When cytotoxicity is evaluated after longer-term exposure, using human and rat monolayers and hepatoma cell lines, the compound is added 1 hr after cell plating and incubated for 23 hr. The loss of intracellular LDH and the MTT test are the endpoints evaluated in cultured cells. The intracellular LDH is measured in the microwell culture plates by a colorimetric method. The MTT test, reduction of the tetrazolium salt MTT to formazan by mitochondrial succinate dehydrogenase, is performed as described. Cytotoxicity in the hepatocyte suspension is evaluated by LDH leakage to the medium after a 2-hr treatment with the drug.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Donato MT, et al. Toxicity of the antitumoral drug datelliptium in hepatic cells: Use of models in vitro for the prediction of toxicity in vivo. Toxicol In Vitro. 1992 Jul;6(4):295-302. [Content Brief]

[2]. Mucci-LoRusso P, et al. Activity of datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice. Invest New Drugs. 1990 Aug;8(3):253-61. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.5129 mL	12.5647 mL	25.1294 mL	62.8235 mL
	5 mM	0.5026 mL	2.5129 mL	5.0259 mL	12.5647 mL
	10 mM	0.2513 mL	1.2565 mL	2.5129 mL	6.2824 mL
	15 mM	0.1675 mL	0.8376 mL	1.6753 mL	4.1882 mL
	20 mM	0.1256 mL	0.6282 mL	1.2565 mL	3.1412 mL
	25 mM	0.1005 mL	0.5026 mL	1.0052 mL	2.5129 mL
	30 mM	0.0838 mL	0.4188 mL	0.8376 mL	2.0941 mL
	40 mM	0.0628 mL	0.3141 mL	0.6282 mL	1.5706 mL
	50 mM	0.0503 mL	0.2513 mL	0.5026 mL	1.2565 mL
	60 mM	0.0419 mL	0.2094 mL	0.4188 mL	1.0471 mL
	80 mM	0.0314 mL	0.1571 mL	0.3141 mL	0.7853 mL
	100 mM	0.0251 mL	0.1256 mL	0.2513 mL	0.6282 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.