Datelliptium chloride hydrochloride
Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from Ellipticine (HY-15753). Datelliptium chloride hydrochloride is effective in vivo against a variety of murine solid tumors.
For research use only. We do not sell to patients.
- CAS No.: 157000-76-5
- Formula: C23H29Cl2N3O
- Molecular Weight:434.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Datelliptium chloride hydrochloride shows cytotoxic effects after 2 hours of treatment in suspension and primary cultures of rat hepatocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Datelliptium chloride hydrochloride (170 mg/kg; i.v; for 12 days) exhibits a high degree of antitumor activity at early staged disease[2].
Datelliptium chloride hydrochloride is selectively cytotoxic for solid tumors over leukemia L1210[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice, colon adenocarcinoma early staged disease model[2]
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Dosage:170 mg/kg
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Administration:Intravenous injection, for 12 days
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Result:Showed potent activity against colon adenocarcinoma.
Chemical Information
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CAS No. 157000-76-5
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Molecular Weight 434.40
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Formula C23H29Cl2N3O
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SMILES
[H]Cl.CC1=C2C(NC3=C2C=C(O)C=C3)=C(C)C4=CC=[N+](CCN(CC)CC)C=C41.[Cl-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Donato MT, et al. Toxicity of the antitumoral drug datelliptium in hepatic cells: Use of models in vitro for the prediction of toxicity in vivo. Toxicol In Vitro. 1992 Jul;6(4):295-302. [Content Brief]
[2]. Mucci-LoRusso P, et al. Activity of datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice. Invest New Drugs. 1990 Aug;8(3):253-61. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Datelliptium chloride hydrochloride Related Classifications
HY-U00337A Related Classifications
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