Photosensitizer-5
Photosensitizer-5 is a photosensitizer. Photosensitizer-5 has cytotoxicity against HeLa and HepG2 cells, with IC50 values of 10.4 nM and 6.9 nM, respectively. Photosensitizer-5 can lead to lipid peroxidation and induces cell death through an iron-independent ferroptosis-like pathway. Photosensitizer-5 shows anti-tumor activity in HeLa tumor-bearing mice.
For research use only. We do not sell to patients.
- Formula: C35H26BF2IN4O2
- Molecular Weight:710.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
>50 μM
Compound: 20
|
Dark cytotoxicity against human HeLa cells assessed as inhibition of cell viability incubated for 3 hrs by CCK8 assay
Dark cytotoxicity against human HeLa cells assessed as inhibition of cell viability incubated for 3 hrs by CCK8 assay
|
[PMID: 39167079] |
| HeLa | IC50 |
10.4 nM
Compound: 20
|
Phototoxicity against human HeLa cells assessed as inhibition of cell viability preincubated for 3 hrs followed by photo-irradiation of 54 J/cm2 for 24 hrs by CCK8 assay
Phototoxicity against human HeLa cells assessed as inhibition of cell viability preincubated for 3 hrs followed by photo-irradiation of 54 J/cm2 for 24 hrs by CCK8 assay
|
[PMID: 39167079] |
| HepG2 | IC50 |
>50 μM
Compound: 20
|
Dark cytotoxicity against human HepG2 cells assessed as inhibition of cell viability incubated for 3 hrs by CCK8 assay
Dark cytotoxicity against human HepG2 cells assessed as inhibition of cell viability incubated for 3 hrs by CCK8 assay
|
[PMID: 39167079] |
| HepG2 | IC50 |
6.9 nM
Compound: 20
|
Phototoxicity against human HepG2 cells assessed as inhibition of cell viability preincubated for 3 hrs followed by photo-irradiation of 54 J/cm2 for 24 hrs by CCK8 assay
Phototoxicity against human HepG2 cells assessed as inhibition of cell viability preincubated for 3 hrs followed by photo-irradiation of 54 J/cm2 for 24 hrs by CCK8 assay
|
[PMID: 39167079] |
Chemical Information
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Molecular Weight 710.32
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Formula C35H26BF2IN4O2
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SMILES
IC1=C(C2=CC=C(OC)C=C2)N3C(N=C4C(C5=CC=CC=C5)=C6CCC7=C(C=CC(OC)=C7)C6=[N+]4[B-](F)3F)=C1C8=CN=CC=C8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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