2. Membrane Transporter/Ion Channel Apoptosis
  3. P-glycoprotein Apoptosis
  4. Phellamurin

Phellamurin is a plant flavonone glycoside from the leaves of Phellodendron amurense and inhibits intestinal P-glycoprotein. Phellamurin also inhibits egg laying by Papilio protenor. Phellamurin induces cells apoptosis and has anti-tumor activity.

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Phellamurin Chemical Structure

Phellamurin Chemical Structure

CAS No. : 52589-11-4

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Phellamurin Related Antibodies

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Description

Phellamurin is a plant flavonone glycoside from the leaves of Phellodendron amurense and inhibits intestinal P-glycoprotein. Phellamurin also inhibits egg laying by Papilio protenor. Phellamurin induces cells apoptosis and has anti-tumor activity[1][2][3].

In Vitro

Phellamurin (0-10 μg/mL; 48 hours; U2OS and Saos-2 cells) treatment leads to a repression of cell viability in U2OS and Saos-2 cells in a dose-dependent manner[1].
Phellamurin (0-10 μg/mL; 48 hours; U2OS and Saos-2 cells) treatment concentration-dependently promots the apoptosis of U2OS and Saos-2 cells[1].
Phellamurin (0-10 μg/mL; 48 hours; U2OS and Saos-2 cells) treatment declines the ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR in U2OS and Saos-2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phellamurin Related Antibodies

Cell Viability Assay[1]

Cell Line: U2OS and Saos-2 cells
Concentration: 0 μg/mL, 2.5 μg/mL, 5 μg/mL, and 10 μg/mL
Incubation Time: 48 hours
Result: Suppressed the viability of U2OS and Saos-2 cells in a concentration-dependent manner.

Apoptosis Analysis[1]

Cell Line: U2OS and Saos-2 cells
Concentration: 0 μg/mL, 2.5 μg/mL, 5 μg/mL, and 10 μg/mL
Incubation Time: 48 hours
Result: Induced apoptosis of U2OS and Saos-2 cells in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: U2OS and Saos-2 cells
Concentration: 0 μg/mL and 10 μg/mL
Incubation Time: 48 hours
Result: Repressed the PI3K/AKT/mTOR pathway in U2OS and Saos-2 cells.
In Vivo

Phellamurin (50 mg/kg/day; intraperitoneal injection; daily; for 21 days; female BALB/c nude mice) treatment represses osteosarcoma tumor growth in vivo. The ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR are decreased in xenograft in Phellamurin-treated mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic female BALB/c nude mice (6 weeks old ) injected with U2OS cells[1]
Dosage: 50 mg/kg/day
Administration: Intraperitoneal injection; daily; for 21 days
Result: Repressed osteosarcoma tumor growth in vivo.
Molecular Weight

518.51

Formula

C26H30O11
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1[C@H](O)[C@@H](C2=CC=C(O)C=C2)OC3=C(C/C=C(C)\C)C(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC(O)=C13
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Phellamurin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phellamurin52589-11-4P-glycoproteinApoptosisP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Flavononeglycosideanti-tumorp-PI3Kp-AKTp-mTORintestinalapoptosisInhibitorinhibitorinhibit

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