Phellamurin
Phellamurin is a plant flavonone glycoside from the leaves of Phellodendron amurense and inhibits intestinal P-glycoprotein. Phellamurin also inhibits egg laying by Papilio protenor. Phellamurin induces cells apoptosis and has anti-tumor activity.
For research use only. We do not sell to patients.
- CAS No.: 52589-11-4
- Formula: C26H30O11
- Molecular Weight:518.51
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Phellamurin (0-10 μg/mL; 48 hours; U2OS and Saos-2 cells) treatment leads to a repression of cell viability in U2OS and Saos-2 cells in a dose-dependent manner[1].
Phellamurin (0-10 μg/mL; 48 hours; U2OS and Saos-2 cells) treatment concentration-dependently promots the apoptosis of U2OS and Saos-2 cells[1].
Phellamurin (0-10 μg/mL; 48 hours; U2OS and Saos-2 cells) treatment declines the ratios of p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR in U2OS and Saos-2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:U2OS and Saos-2 cells
-
Concentration:0 μg/mL, 2.5 μg/mL, 5 μg/mL, and 10 μg/mL
-
Incubation Time:48 hours
-
Result:Suppressed the viability of U2OS and Saos-2 cells in a concentration-dependent manner.
-
Cell Line:U2OS and Saos-2 cells
-
Concentration:0 μg/mL, 2.5 μg/mL, 5 μg/mL, and 10 μg/mL
-
Incubation Time:48 hours
-
Result:Induced apoptosis of U2OS and Saos-2 cells in a concentration-dependent manner.
-
Cell Line:U2OS and Saos-2 cells
-
Concentration:0 μg/mL and 10 μg/mL
-
Incubation Time:48 hours
-
Result:Repressed the PI3K/AKT/mTOR pathway in U2OS and Saos-2 cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Athymic female BALB/c nude mice (6 weeks old ) injected with U2OS cells[1]
-
Dosage:50 mg/kg/day
-
Administration:Intraperitoneal injection; daily; for 21 days
-
Result:Repressed osteosarcoma tumor growth in vivo.
Chemical Information
-
CAS No. 52589-11-4
-
Appearance Solid
-
Molecular Weight 518.51
-
Formula C26H30O11
-
Color Light yellow to yellow
-
SMILES
O=C1[C@H](O)[C@@H](C2=CC=C(O)C=C2)OC3=C(C/C=C(C)\C)C(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC(O)=C13
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
-
Handling Instructions (2659 KB)
References
[1]. Hongzhi Zhang, et al. Anti-tumor Efficacy of Phellamurin in Osteosarcoma Cells: Involvement of the PI3K/AKT/mTOR Pathway. Eur J Pharmacol. 2019 Sep 5;858:172477. [Content Brief]
[2]. Hung-Yi Chen, et al. Marked Decrease of Cyclosporin Absorption Caused by Phellamurin in Rats. Planta Med. 2002 Feb;68(2):138-41. [Content Brief]
[3]. Keiichi Honda, et al. Synergistic or Antagonistic Modulation of Oviposition Response of Two Swallowtail Butterflies, Papilio Maackii and P. Protenor, to Phellodendron Amurense by Its Constitutive Prenylated Flavonoid, Phellamurin. J Chem Ecol. 2011 Jun;37(6):575-81. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phellamurin Related Classifications
HY-N3085 Related Classifications
Powered by Bioz