Purpurin 18
Based on 2 publication(s) in Google Scholar
Purpurin 18, a derivative of chlorophyll and a type of dihydroporphyrin, is used to produce photosensitizers. Purpurin 18 photodynamic therapy can induce cell apoptosis and has anti-tumor activity.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 25465-77-4
- Formula: C33H32N4O5
- Molecular Weight:564.63
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Purpurin 18
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Biological Activity
Purpurin 18 (0-10 μM, 24 h) shows cytotoxicity to 4T1 cells under light reaction conditions, exhibiting strong photodynamic activity[1].
Purpurin 18 (0.5 μM, 4 h) PDT treatment induces apoptosis in 2D cultured 4T1 cells[1].
Purpurin 18 is mainly accumulated in the lysosomes of 4T1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:4T1
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Concentration:0, 0.25, 0.5, 1, 2, 4, 8, 10 μM
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Incubation Time:24 h
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Result:Was non-cytotoxic at doses below 4 μM in the absence of light, but was cytotoxic when combined with light.
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Cell Line:4T1 (PTD)
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Concentration:0.5 μM
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Incubation Time:4 h
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Result:Induced 50% cell apoptosis.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Subcutaneous injection of 4T1 mouse model (PDT treatment)[1]
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Dosage:0.625 mg/kg; single dose
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Administration:Intratumoral injection
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Result:Had good photodynamic efficacy, did not affect body weight and major organ functions, and inhibited tumor proliferation.
Chemical Information
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CAS No. 25465-77-4
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Appearance Solid
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Molecular Weight 564.63
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Formula C33H32N4O5
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Color Brown to black
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SMILES
O=C(O1)/C2=C([C@H]3CCC(O)=O)/N=C([C@H]3C)/C=C(C(C)=C/4C=C)\NC4=C/C5=N/C(C(CC)=C5C)=C\C6=C(C)C(C1=O)=C2N6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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Nat Commun
Pre-activated nanoparticles with persistent luminescence for deep tumor photodynamic therapy in gallbladder cancer. [Abstract]2023 Sep 14;14(1):5699. PMID: 37709778 -
Int J Pharm
PLGA-based nanocarriers for combined delivery of colchicine and purpurin 18 in cancer therapy: Multimodal approach employing cancer cell spheroids. [Abstract]2024 May 25:657:124170. PMID: 38679244
Solvent & Solubility
DMSO : 10 mg/mL (17.71 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : < 1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (285 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Pengyun Huang, et al. Photodynamic treatment with purpurin 18 effectively inhibits triple negative breast cancer by inducing cell apoptosis. Lasers Med Sci. 2021 Mar;36(2):339-347. [Content Brief]
[2]. NicolasDrogat, et al. High yield preparation of purpurin-18 from Spirulina maxima. Dyes and Pigments
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7711 mL | 8.8554 mL | 17.7107 mL | 44.2768 mL |
| 5 mM | 0.3542 mL | 1.7711 mL | 3.5421 mL | 8.8554 mL | |
| 10 mM | 0.1771 mL | 0.8855 mL | 1.7711 mL | 4.4277 mL | |
| 15 mM | 0.1181 mL | 0.5904 mL | 1.1807 mL | 2.9518 mL |
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