AXL-IN-14 

AXL-IN-14 is a potent and orally active AXL inhibitor with an IC₅₀ value of 0.8 nM. AXL-IN-14 inhibits Gas6/AXL-mediated cell migration and invasion. AXL-IN-14 decreases the expression of p-AXL and p-AKT proteins. AXL-IN-14 shows anti-tumor activity^[1].

IC₅₀: 0.8 nM (AXL)^[1]

AXL-IN-14 (0.2, 1, 5 nM; 1 h) decreases the expression of p-AXL and p-AKT protein levels in a dose-dependent manner^[1].
AXL-IN-14 (72 h) shows antiproliferative activity with an IC₅₀ value of 21.8 nM for EBC-1 Cells^[1].
AXL-IN-14 (20, 100 nM; 24 h) inhibits Gas6/AXL-mediated cell migration and invasion in H1299 and SNU449 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AXL-IN-14 (1, 10 mg/kg; p.o.; once daily for 11 days) shows anti-tumor activity in nude mouse^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

566.55

C₃₂H₂₄F₂N₄O₄

2947506-65-0

FC1=CC(NC(C2=CN(C=C(C2=O)C3=CC=C(C=C3)F)C(C)C)=O)=CC=C1OC4=CC=NC5=C4OC6=CC=CC=C6N5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhengsheng Zhan, et al. Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase. J. Med. Chem. 2022.