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Cat. No.: HY-152075

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AXL-IN-14

AXL-IN-14 is a potent and orally active AXL inhibitor with an IC₅₀ value of 0.8 nM. AXL-IN-14 inhibits Gas6/AXL-mediated cell migration and invasion. AXL-IN-14 decreases the expression of p-AXL and p-AKT proteins. AXL-IN-14 shows anti-tumor activity.

For research use only. We do not sell to patients.

CAS No.: 2947506-65-0
Formula: C₃₂H₂₄F₂N₄O₄
Molecular Weight:566.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

AXL-IN-14 Chemical Structure

CAS No.: 2947506-65-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Axl

All TAM Receptor Isoforms :

In Vitro

AXL-IN-14 (0.2, 1, 5 nM; 1 h) decreases the expression of p-AXL and p-AKT protein levels in a dose-dependent manner^[1].
AXL-IN-14 (72 h) shows antiproliferative activity with an IC₅₀ value of 21.8 nM for EBC-1 Cells^[1].
AXL-IN-14 (20, 100 nM; 24 h) inhibits Gas6/AXL-mediated cell migration and invasion in H1299 and SNU449 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

BaF3/TEL-AXL cells
Concentration:

0.2, 1, 5 nM
Incubation Time:

1 h
Result:

Inhibited the expression of p-AXL and p-AKT protein level in a dose-dependent manner.

In Vivo

AXL-IN-14 (1, 10 mg/kg; p.o.; once daily for 11 days) shows anti-tumor activity in nude mouse^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Nude mice (BaF3/TEL-AXL xenograft model)^[1]
Dosage:

1, 10 mg/kg
Administration:

P.o.; once daily for 11 days
Result:

Significantly suppressed tumor growth.

Chemical Information

CAS No. 2947506-65-0
Molecular Weight 566.55
Formula C₃₂H₂₄F₂N₄O₄
SMILES

FC1=CC(NC(C2=CN(C=C(C2=O)C3=CC=C(C=C3)F)C(C)C)=O)=CC=C1OC4=CC=NC5=C4OC6=CC=CC=C6N5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhengsheng Zhan, et al. Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase. J. Med. Chem. 2022.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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AXL-IN-14

All TAM Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

AXL-IN-14 Related Classifications

HY-152075 Related Classifications