2947506-65-0
2947506-65-0
Chemical Structure
AXL-IN-14
- CAS No.: 2947506-65-0
- Formula:C32H24F2N4O4
- Molecular Weight:566.55
IUPAC Name: N-(4-((10H-benzo[b]pyrido[2,3-e][1,4]oxazin-4-yl)oxy)-3-fluorophenyl)-5-(4-fluorophenyl)-1-isopropyl-4-oxo-1,4-dihydropyridine-3-carboxamide
InChIKey: IVRKZMDXSUEQLM-UHFFFAOYSA-N
SMILES: FC1=CC(NC(C2=CN(C=C(C2=O)C3=CC=C(C=C3)F)C(C)C)=O)=CC=C1OC4=CC=NC5=C4OC6=CC=CC=C6N5
Biological Activity: AXL-IN-14 is a potent and orally active AXL inhibitor with an IC50 value of 0.8 nM. AXL-IN-14 inhibits Gas6/AXL-mediated cell migration and invasion. AXL-IN-14 decreases the expression of p-AXL and p-AKT proteins. AXL-IN-14 shows anti-tumor activity[1].
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AXL-IN-14 | AXL-IN-14 is a potent and orally active AXL inhibitor with an IC50 value of 0.8 nM. AXL-IN-14 inhibits Gas6/AXL-mediated cell migration and invasion. AXL-IN-14 decreases the expression of p-AXL and p-AKT proteins. AXL-IN-14 shows anti-tumor activity. | |||||||||||||||||||||
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