2. PROTAC
  3. PROTACs
  4. AD4

AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC50: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy.

For research use only. We do not sell to patients.

AD4 Chemical Structure

AD4 Chemical Structure

CAS No. : 2918262-09-4

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1 mg USD 390 In-stock
5 mg USD 980 In-stock
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Based on 1 publication(s) in Google Scholar

AD4 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE AD4

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Description

AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC50: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy[1].

IC50 & Target

IC50: 0.6 nM (PCLAF/KIAA0101)[1]
Molecular Weight

1035.23

Formula

C55H78N4O15
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

C[C@@H]1[C@@]2([H])[C@]34[C@@](O[C@@H]1OCCN(C(CCCCCCCNC5=C6C(C(N(C7C(NC(CC7)=O)=O)C6=O)=O)=CC=C5)=O)CCO[C@H]8O[C@@]9([H])[C@]%10%11[C@](CC[C@H]([C@]%10([H])CC[C@](O9)(OO%11)C)C)([H])[C@H]8C)([H])O[C@](OO3)(CC[C@@]4([H])[C@@H](CC2)C)C
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (96.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9660 mL 4.8298 mL 9.6597 mL
5 mM 0.1932 mL 0.9660 mL 1.9319 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9660 mL 4.8298 mL 9.6597 mL 24.1492 mL
5 mM 0.1932 mL 0.9660 mL 1.9319 mL 4.8298 mL
10 mM 0.0966 mL 0.4830 mL 0.9660 mL 2.4149 mL
15 mM 0.0644 mL 0.3220 mL 0.6440 mL 1.6099 mL
20 mM 0.0483 mL 0.2415 mL 0.4830 mL 1.2075 mL
25 mM 0.0386 mL 0.1932 mL 0.3864 mL 0.9660 mL
30 mM 0.0322 mL 0.1610 mL 0.3220 mL 0.8050 mL
40 mM 0.0241 mL 0.1207 mL 0.2415 mL 0.6037 mL
50 mM 0.0193 mL 0.0966 mL 0.1932 mL 0.4830 mL
60 mM 0.0161 mL 0.0805 mL 0.1610 mL 0.4025 mL
80 mM 0.0121 mL 0.0604 mL 0.1207 mL 0.3019 mL
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AD4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AD42918262-09-4AD 4AD-4PROTACsInhibitorinhibitorinhibit

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