Tumor targeted pro-apoptotic peptide
Tumor targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2) is an anti-tumor peptide. Tumor targeted pro-apoptotic peptide disrupts mitochondrial membranes and promotes apoptosis, showing anticancer activity in mice.
For research use only. We do not sell to patients.
- CAS No.: 1926163-30-5
- Formula: C94H174N32O22S2
- Molecular Weight:2168.72
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Tumor targeted pro-apoptotic peptide (10 µM; 0-20 min) induces mitochondrial swelling in DMECs[1].
Tumor targeted pro-apoptotic peptide (100 µM; 72 h) induces apoptosis in DMECs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:DMECs
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Concentration:10 µM
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Incubation Time:0-20 min
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Result:Induced considerable mitochondrial swelling at a concentration of 10 µM, and mild swelling was evident even at 3 µM.
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Cell Line:DMECs
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Concentration:100 µM
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Incubation Time:72 h
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Result:Showed the classic morphological indicators of apoptosis, including nuclear condensation and fragmentation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Tumor targeted pro-apoptotic peptide (250 µg/mice; tail vein injection; 250 µg a week for 17 weeks) inhibits both primary tumor growth and metastasis in mice[1].
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Dosage:250 µg/mice
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Administration:Tail vein injection; 250 µg a week for 17 weeks
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Result:Exhibited antitumor activity in vivo.
Chemical Information
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CAS No. 1926163-30-5
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Molecular Weight 2168.72
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Formula C94H174N32O22S2
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Sequence Shortening
CNGRCGGKLAKLAKKLAKLAK-NH2 (Disulfide bridge:Cys1-Cys5)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tumor targeted pro-apoptotic peptide Related Classifications
HY-P3707 Related Classifications
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