2. Apoptosis
  3. Apoptosis
  4. Tumor targeted pro-apoptotic peptide

Tumor targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2) is an anti-tumor peptide. Tumor targeted pro-apoptotic peptide disrupts mitochondrial membranes and promotes apoptosis, showing anticancer activity in mice.

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Tumor targeted pro-apoptotic peptide Chemical Structure

Tumor targeted pro-apoptotic peptide Chemical Structure

CAS No. : 1926163-30-5

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Tumor targeted pro-apoptotic peptide Related Antibodies

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Description

Tumor targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2) is an anti-tumor peptide. Tumor targeted pro-apoptotic peptide disrupts mitochondrial membranes and promotes apoptosis, showing anticancer activity in mice[1].

In Vitro

Tumor targeted pro-apoptotic peptide (10 µM; 0-20 min) induces mitochondrial swelling in DMECs[1].
Tumor targeted pro-apoptotic peptide (100 µM; 72 h) induces apoptosis in DMECs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tumor targeted pro-apoptotic peptide Related Antibodies

Cell Viability Assay[1]

Cell Line: DMECs
Concentration: 10 µM
Incubation Time: 0-20 min
Result: Induced considerable mitochondrial swelling at a concentration of 10 µM, and mild swelling was evident even at 3 µM.

Apoptosis Analysis[1]

Cell Line: DMECs
Concentration: 100 µM
Incubation Time: 72 h
Result: Showed the classic morphological indicators of apoptosis, including nuclear condensation and fragmentation.
In Vivo

Tumor targeted pro-apoptotic peptide inhibits both primary tumor growth and metastasis in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tumor targeted pro-apoptotic peptide (250 µg/mice; tail vein injection; 250 µg a week for 17 weeks) inhibits both primary tumor growth and metastasis in mice[1].
Dosage: 250 µg/mice
Administration: Tail vein injection; 250 µg a week for 17 weeks
Result: Exhibited antitumor activity in vivo.
Molecular Weight

2168.72

Formula

C94H174N32O22S2
CAS No.
Sequence Shortening

CNGRCGGKLAKLAKKLAKLAK-NH2 (Disulfide bridge:Cys1-Cys5)
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tumor targeted pro-apoptotic peptide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tumor targeted pro-apoptotic peptide1926163-30-5ApoptosiscancertumorapoptosisantibacterialDMECsInhibitorinhibitorinhibit

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Tumor targeted pro-apoptotic peptide
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