ATM Inhibitor-10
Based on 1 Customer Validation
ATM Inhibitor-10 (compound 74), a 3-quinoline carboxamide, is a highly selective and orally active ATM inhibitor (IC50: 0.6 nM). ATM Inhibitor-10 has anti-tumor activity in SW620 xenograft models. ATM Inhibitor-10 is synergistic with Top I inhibitors.
For research use only. We do not sell to patients.
- Purity: 98.7%
- CAS No.: 1941214-06-7
- Formula: C23H23FN6O2
- Molecular Weight:434.47
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Kinase Inhibitor Library
HY-L009
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PI3K/Akt/mTOR Compound Library
HY-L015
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Oxygen Sensing Compound Library
HY-L045
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Glycolysis Compound Library
HY-L058
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Cytoskeleton Compound Library
HY-L060
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Orally Active Compound Library
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Anti-Pancreatic Cancer Compound Library
HY-L077
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Anti-Cancer Metabolism Compound Library
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Anti-Obesity Compound Library
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Glucose Metabolism Compound Library
HY-L092
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Cancer Stem Cells Compound Library
HY-L135
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Highly Selective Inhibitors Library
HY-L158
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Serine/Threonine Kinase Inhibitor Library
HY-L164
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Anti-Ovarian Cancer Compound Library
HY-L173
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
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High-Efficiency Gene Editing Compound Library
HY-L244
Biological Activity
0.6 nM (ATM), 370 nM (DNAPK), 1.48 μM (mTOR), 0.445 μM (PI3Kα), 12.8 μM (PI3Kβ), 7.1 μM (PI3Kγ)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | IC50 |
>19 μM
Compound: 74
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Inhibition of ATR in human HT-29 cells assessed as reduction in Chk1 phosphorylation at Ser-345 residue after 60 mins in presence of 4-nitroquinoline-1-oxide by Hoechst 33258 staining based plate reader analysis
Inhibition of ATR in human HT-29 cells assessed as reduction in Chk1 phosphorylation at Ser-345 residue after 60 mins in presence of 4-nitroquinoline-1-oxide by Hoechst 33258 staining based plate reader analysis
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[PMID: 27259031] |
| HT-29 | IC50 |
>30 μM
Compound: 74
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Inhibition of DNAPK phosphorylation at Ser-2056 residue in human HT-29 cells
Inhibition of DNAPK phosphorylation at Ser-2056 residue in human HT-29 cells
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[PMID: 27259031] |
| HT-29 | IC50 |
0.033 μM
Compound: 74
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Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based fluorescence plate reader analysis
Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based fluorescence plate reader analysis
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[PMID: 27259031] |
Chemical Information
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CAS No. 1941214-06-7
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Appearance Solid
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Molecular Weight 434.47
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Formula C23H23FN6O2
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Color Off-white to gray
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SMILES
O=C(C1=C(N[C@H](C2=NN(C)C=C2)C)C3=CC(C4=CC=C(COC)N=C4)=C(F)C=C3N=C1)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (287.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3017 mL | 11.5083 mL | 23.0165 mL | 57.5414 mL |
| 5 mM | 0.4603 mL | 2.3017 mL | 4.6033 mL | 11.5083 mL | |
| 10 mM | 0.2302 mL | 1.1508 mL | 2.3017 mL | 5.7541 mL | |
| 15 mM | 0.1534 mL | 0.7672 mL | 1.5344 mL | 3.8361 mL | |
| 20 mM | 0.1151 mL | 0.5754 mL | 1.1508 mL | 2.8771 mL | |
| 25 mM | 0.0921 mL | 0.4603 mL | 0.9207 mL | 2.3017 mL | |
| 30 mM | 0.0767 mL | 0.3836 mL | 0.7672 mL | 1.9180 mL | |
| 40 mM | 0.0575 mL | 0.2877 mL | 0.5754 mL | 1.4385 mL | |
| 50 mM | 0.0460 mL | 0.2302 mL | 0.4603 mL | 1.1508 mL | |
| 60 mM | 0.0384 mL | 0.1918 mL | 0.3836 mL | 0.9590 mL | |
| 80 mM | 0.0288 mL | 0.1439 mL | 0.2877 mL | 0.7193 mL | |
| 100 mM | 0.0230 mL | 0.1151 mL | 0.2302 mL | 0.5754 mL |
ATM Inhibitor-10 Related Classifications
HY-118911 Related Classifications
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