2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR
  4. ATM Inhibitor-10

ATM Inhibitor-10 (compound 74), a 3-quinoline carboxamide, is a highly selective and orally active ATM inhibitor (IC50: 0.6 nM). ATM Inhibitor-10 has anti-tumor activity in SW620 xenograft models. ATM Inhibitor-10 is synergistic with Top I inhibitors.

For research use only. We do not sell to patients.

ATM Inhibitor-10 Chemical Structure

ATM Inhibitor-10 Chemical Structure

CAS No. : 1941214-06-7

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ATM Inhibitor-10 Related Antibodies

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Description

ATM Inhibitor-10 (compound 74), a 3-quinoline carboxamide, is a highly selective and orally active ATM inhibitor (IC50: 0.6 nM). ATM Inhibitor-10 has anti-tumor activity in SW620 xenograft models. ATM Inhibitor-10 is synergistic with Top I inhibitors[1].

IC50 & Target

0.6 nM (ATM), 370 nM (DNAPK), 1.48 μM (mTOR), 0.445 μM (PI3Kα), 12.8 μM (PI3Kβ), 7.1 μM (PI3Kγ)[1]
Molecular Weight

434.47

Formula

C23H23FN6O2
CAS No.
SMILES

O=C(C1=C(N[C@H](C2=NN(C)C=C2)C)C3=CC(C4=CC=C(COC)N=C4)=C(F)C=C3N=C1)N
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ATM Inhibitor-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATM Inhibitor-101941214-06-7ATM Inhibitor10ATM Inhibitor 10ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 related3-Quinolinecarboxamideeffective orallyInhibitorinhibitorinhibit

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