Hesperetin triacetate
Hesperetin triacetate is an active compound with anti-inflammatory and anti-tumor activities. Hesperetin triacetate inhibits bovine serum albumin denaturation in vitro. Hesperetin triacetate inhibits carrageenan-induced paw swelling in mice in vivo. Hesperetin triacetate exhibits anti-proliferative activity against breast cancer cells. Hesperetin triacetate induces DNA degradation and apoptosis in breast cancer cells. Hesperetin triacetate can be used in studies related to breast cancer and inflammation.
For research use only. We do not sell to patients.
- CAS No.: 73489-97-1
- Formula: C22H20O9
- Molecular Weight:428.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Hesperetin triacetate (compound 4b) potently inhibits the proliferation of human breast cancer MCF-7 cells at 48 h[1].
Hesperetin triacetate (36-48 h) induces apoptotic DNA fragmentation in human breast cancer MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 human breast cancer cells
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Concentration:Concentrations to determine IC50
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Incubation Time:48 h
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Result:Exhibited anti-proliferative activity against MCF-7 cells with an IC50 of 0.020 ± 0.001 μmol/mL.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice treated carrageenan (22 ± 2 g)[1]
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Dosage:5% cream formulation
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Administration:topical; twice daily; 6 days
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Result:Reduced paw edema to 68.25 ± 5.68% at 3 hours post-carrageenan injection.
Reduced paw edema to 54.2 ± 10.5% at 1 day post-carrageenan injection.
Reduced paw edema to 46.34 ± 7.21% at 2 days post-carrageenan injection.
Reduced paw edema to 48.15 ± 5.36% at 3 days post-carrageenan injection.
Reduced paw edema to 36.41 ± 9.59% at 4 days post-carrageenan injection.
Reduced paw edema to 17.64 ± 6.35% at 5 days post-carrageenan injection.
Reduced paw edema to 19.67 ± 4.46% at 6 days post-carrageenan injection.
Chemical Information
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CAS No. 73489-97-1
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Molecular Weight 428.39
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Formula C22H20O9
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SMILES
O(C(C)=O)C1=C2C(O[C@@H](CC2=O)C3=CC(OC(C)=O)=C(OC)C=C3)=CC(OC(C)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hesperetin triacetate Related Classifications
HY-W778375 Related Classifications
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