Cizutamig
Based on 1 Customer Validation
Cizutamig (CND-106) is a bispecific T-cell engager targeting BCMA and CD3. Cizutamig exhibits immunostimulatory and anti-tumor activities. Cizutamig can be used in research related to relapsed or refractory multiple myeloma and systemic lupus erythematosus.
For research use only. We do not sell to patients.
- Purity: 95%
- CAS No.: 2919209-65-5
- Molecular Weight:241.429 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
[L-kappa-H-gamma1_[VH-G1(CH1-h)]_Lkappa] dimer
Human
TNFRSF17 & CD3E
Cizutamig exhibits binding affinity to BCMA-expressing myeloma cell lines comparable to that of T cell engagers (TCEs), while its binding affinity to CD3-positive Jurkat T cells is lower than that of the benchmark BCMA×CD3 TCE[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Cynomolgus monkeys[1]
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Dosage:0.5 mg/kg
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Administration:i.v.; single dose
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Result:Caused transient decrease in peripheral blood T cells indicative of margination.
Sustained reductions in circulating B cells.
Induced limited, transient cytokines.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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VK-CK-VH-CH1-h-CH2-CH3_L-kappa_Fab-G1-kappa
ELISA, FACS, Functional assay
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Loaded Cizutamig on ProA biosensor, can bind BCMA/TNFRSF17 Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78070) with an affinity constant of 8.191E-11 M as determined in BLI assay.
Chemical Information
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CAS No. 2919209-65-5
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Appearance Liquid
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Molecular Weight 241.429 kDa
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Color Colorless to light yellow
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SMILES
[Cizutamig]
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Synonyms
CND-106; EMB-06
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)