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Cat. No.: HY-P990980

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Biologically Validated

Cizutamig

Name: Cizutamig
Brand: MedChemExpress
SKU: HY-P990980
Price: 650.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: CND-106; EMB-06)

Customer Review

Based on 1 Customer Validation

Cizutamig (CND-106) is a bispecific T-cell engager targeting BCMA and CD3. Cizutamig exhibits immunostimulatory and anti-tumor activities. Cizutamig can be used in research related to relapsed or refractory multiple myeloma and systemic lupus erythematosus.

For research use only. We do not sell to patients.

Purity : 99.00%
CAS No.: 2919209-65-5
Molecular Weight:241.429 kDa

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cizutamig Chemical Structure

CAS No.: 2919209-65-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Verified Bioactivity
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Isotype

[L-kappa-H-gamma1_[VH-G1(CH1-h)]_Lkappa] dimer

Species Reactivity

Human

IC₅₀ & Target

TNFRSF17 & CD3E

In Vitro

Cizutamig exhibits binding affinity to BCMA-expressing myeloma cell lines comparable to that of T cell engagers (TCEs), while its binding affinity to CD3-positive Jurkat T cells is lower than that of the benchmark BCMA×CD3 TCE^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

Cizutamig (0.5 mg/kg; intravenous administration; single dose) induces transient T cell margination, persistent B cell depletion, and mild transient cytokine induction in healthy cynomolgus monkeys^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Cynomolgus monkeys^[1]
Dosage:

0.5 mg/kg
Administration:

i.v.; single dose
Result:

Caused transient decrease in peripheral blood T cells indicative of margination.
Sustained reductions in circulating B cells.
Induced limited, transient cytokines.

Gene ID

608 [NCBI] & 916 [NCBI]

Accession

Q02223 & P07766

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

VK-CK-VH-CH1-h-CH2-CH3_L-kappa_Fab-G1-kappa

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized CD3 epsilon Protein, Human (HEK293, HY-P70506) can bind Cizutamig. The ED₅₀ for this effect is 5.73 ng/mL.
Loaded Cizutamig on ProA biosensor, can bind BCMA/TNFRSF17 Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78070) with an affinity constant of 8.191E-11 M as determined in BLI assay.

Chemical Information

CAS No. 2919209-65-5
Appearance Liquid
Molecular Weight 241.429 kDa
Color Colorless to light yellow
SMILES

[Cizutamig]
Synonyms

CND-106; EMB-06
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Tan P, et al. POS1141 CND106, a novel BCMA-directed T-cell engager (TCE), has a differentiated safety profile and potential for development in autoantibody-driven autoimmune diseases. Annals of the Rheumatic Diseases, 2025, 84: 1217.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- Isotype
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Biological Activity
Chemical Information
Purity & Documentation
References

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VK-CK-VH-CH1-h-CH2-CH3_L-kappa_Fab-G1-kappa
1/16

Immobilized CD3 epsilon Protein, Human (HEK293, HY-P70506) can bind Cizutamig. The ED₅₀ for this effect is 5.73 ng/mL.
1/16

Loaded Cizutamig on ProA biosensor, can bind BCMA/TNFRSF17 Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78070) with an affinity constant of 8.191E-11 M as determined in BLI assay.
1/16

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Cizutamig