2. Peptides
  3. Peptide and Derivatives
  4. Inhibitors and Substrates
  5. Phakellistatin 13

Phakellistatin 13 is a natural cycloheptapeptide with anti-tumor activity. Phakellistatin 13 exhibits a potent inhibitory effect on liver cancer cells BEL-7404 (ED500 < 0.01 μg/mL). Phakellistatin 13 can be used for research on liver cancer.

For research use only. We do not sell to patients.

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Phakellistatin 13

Phakellistatin 13 Chemical Structure

CAS No. : 493012-52-5

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Phakellistatin 13 Related Antibodies

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Description

Phakellistatin 13 is a natural cycloheptapeptide with anti-tumor activity. Phakellistatin 13 exhibits a potent inhibitory effect on liver cancer cells BEL-7404 (ED500 < 0.01 μg/mL). Phakellistatin 13 can be used for research on liver cancer[1].

Cellular Effect
Cell Line Type Value Description References
4T1 IC50
26.8 μM
Compound: Phakellistatin 13
Antiproliferative activity against mouse 4T1 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against mouse 4T1 cells incubated for 48 hrs by MTT assay
[PMID: 38990190]
Bel-7402 ED50
< 0.01 μg/mL
Compound: 3
Cytotoxicity against human Bel-7402
Cytotoxicity against human Bel-7402
[PMID: 17190452]
HeLa IC50
28.05 μM
Compound: Phakellistatin 13
Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay
[PMID: 38990190]
HepG2 IC50
13.1 μM
Compound: Phakellistatin 13
Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay
[PMID: 38990190]
L929 IC50
> 100 μM
Compound: Phakellistatin 13
Antiproliferative activity against mouse L929 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against mouse L929 cells incubated for 48 hrs by MTT assay
[PMID: 38990190]
MDA-MB-231 IC50
20.5 μM
Compound: Phakellistatin 13
Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay
[PMID: 38990190]
Molecular Weight

798.93

Formula

C42H54N8O8
CAS No.
Sequence

cyclo(Pro-Phe-Gly-Pro-Thr-Leu-Trp)
Sequence Shortening

cyclo(PFGPTLW)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Phakellistatin 13 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phakellistatin 13493012-52-5Otherscyclic peptidyl antitumor agentsisoindolinoneconformational constraintp53 signaling pathwayMAPK signaling pathwaymolecular dockingtranscriptome analysisapoptosis inductionhepatocellular carcinomInhibitorinhibitorinhibit

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