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製品番号: HY-129407A

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AAF-CMK

AAF-CMK is a TPPII (tripeptidylpeptidase II) inhibitor, shows anti-tumor activity and induces apoptosis. AAF-CMK can be used in leukemia research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 102129-66-8
分子式: C₁₆H₂₂ClN₃O₃
分子量:339.82

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

AAF-CMK 構造式

CAS 番号: 102129-66-8

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価格（税別）

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

AAF-CMK is a TPPII (tripeptidylpeptidase II) inhibitor, shows anti-tumor activity and induces apoptosis. AAF-CMK can be used in leukemia research^[1].

体外実験

AAF-CMK (0-20 μM; 24 h) shows potentiated antitumor effects of U937 leukemia cells in combination with TRAIL or TNF^[1].
AAF-CMK (20 μM; 24 h) increases TNF- and TRAIL-induced U937 cell apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

U937 human promonocytic leukemia cells
Concentration:

0-20 μM
Incubation Time:

24 h
Result:

Resulted in the potentiation of growth inhibitory cytostatic effects of TRAIL as well as TNF.

Apoptosis Analysis^[1]

Cell Line:

U937 human promonocytic leukemia cells
Concentration:

20 μM
Incubation Time:

24 h
Result:

Increased the percentage of apoptotic cells to 55.8% in combination with TRAIL.
Increased number of cells with characteristic apoptotic morphology in groups treated with AAF-CMK and both TRAIL or TNF compared to each group treated alone.

化学情報

CAS 番号 102129-66-8
分子量 339.82
分子式 C₁₆H₂₂ClN₃O₃
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Młnarczuk I, et al. AAF-cmk sensitizes tumor cells to trail-mediated apoptosis. Leuk Res. 2004 Jan;28(1):53-61. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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