2. Metabolic Enzyme/Protease Apoptosis
  3. Ser/Thr Protease Apoptosis
  4. AAF-CMK

AAF-CMK is a TPPII (tripeptidylpeptidase II) inhibitor, shows anti-tumor activity and induces apoptosis. AAF-CMK can be used in leukemia research.

For research use only. We do not sell to patients.

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AAF-CMK Chemical Structure

AAF-CMK Chemical Structure

CAS No. : 102129-66-8

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AAF-CMK Related Antibodies

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Description

AAF-CMK is a TPPII (tripeptidylpeptidase II) inhibitor, shows anti-tumor activity and induces apoptosis. AAF-CMK can be used in leukemia research[1].

In Vitro

AAF-CMK (0-20 μM; 24 h) shows potentiated antitumor effects of U937 leukemia cells in combination with TRAIL or TNF[1].
AAF-CMK (20 μM; 24 h) increases TNF- and TRAIL-induced U937 cell apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AAF-CMK Related Antibodies

Cell Viability Assay[1]

Cell Line: U937 human promonocytic leukemia cells
Concentration: 0-20 μM
Incubation Time: 24 h
Result: Resulted in the potentiation of growth inhibitory cytostatic effects of TRAIL as well as TNF.

Apoptosis Analysis[1]

Cell Line: U937 human promonocytic leukemia cells
Concentration: 20 μM
Incubation Time: 24 h
Result: Increased the percentage of apoptotic cells to 55.8% in combination with TRAIL.
Increased number of cells with characteristic apoptotic morphology in groups treated with AAF-CMK and both TRAIL or TNF compared to each group treated alone.
Molecular Weight

339.82

Formula

C16H22ClN3O3
CAS No.
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Purity & Documentation
References
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AAF-CMK Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AAF-CMK102129-66-8Ser/Thr ProteaseApoptosisSerine proteasesSerine endopeptidasesThreonine proteasesanti-tumor activityinduce apoptosisleukemiaInhibitorinhibitorinhibit

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