T-3256336
T-3256336 is a potent and orally active cIAP1 and XIAP inhibitor with IC50s of 1.3, 200 nM, respectively. T-3256336 shows anti-tumor activity.
For research use only. We do not sell to patients.
- CAS No.: 1266227-69-3
- Formula: C31H45F2N5O5
- Molecular Weight:605.72
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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cIAP1 1.3 nM (IC50) |
XIAP 200 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| MDA-MB-231 | GI50 |
1.8 nM
Compound: 45, T-3256336
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Growth inhibition of human MDA-MB-231 cells assessed as cell viability after 3 days by CellTitre-Glo Luminescent assay
Growth inhibition of human MDA-MB-231 cells assessed as cell viability after 3 days by CellTitre-Glo Luminescent assay
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[PMID: 23298277] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/cAJcl mice (MDA-MB-231-Luc xenograft)[1]
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Dosage:30, 100 mg/kg
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Administration:P.o.
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Result:Stimulated caspase-3/7 activity in a dose-dependent manner, induced tumor regression in a dose-dependent manner with a percent tumor growth inhibition (T/C) of 53% and 62% at 30 mg/kg and 100 mg/kg, respectively.
Chemical Information
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CAS No. 1266227-69-3
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Appearance Solid
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Molecular Weight 605.72
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Formula C31H45F2N5O5
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Color White to off-white
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SMILES
O=C([C@H]1N(C([C@H](C2CCC(F)(F)CC2)NC([C@@H](NC)C)=O)=O)C[C@](C[C@@H](OCC)C3)([H])N3C1)N[C@@H]4CCOC5=CC=CC=C45
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
T-3256336 Related Classifications
HY-100682 Related Classifications
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