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ATIC-IN-1 (compound 14) acetate is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 acetate exhibits anti-tumor activity via reduction in cell numbers and cell division rates.

For research use only. We do not sell to patients.

ATIC-IN-1 acetate Chemical Structure

ATIC-IN-1 acetate Chemical Structure

Size Price Stock Quantity
5 mg USD 165 In-stock
10 mg USD 265 In-stock
25 mg USD 550 In-stock
50 mg USD 880 In-stock
100 mg USD 1420 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of ATIC-IN-1 acetate:

ATIC-IN-1 acetate Related Antibodies

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Description

ATIC-IN-1 (compound 14) acetate is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 acetate exhibits anti-tumor activity via reduction in cell numbers and cell division rates[1].

In Vitro

ATIC-IN-1 acetate (10 μM, 50 μM) is a specific inhibitor, and shows nonspecific aggregate mechanism in the present of 1 mg/mL and 10 mg/mL BSA[1].
ATIC-IN-1 acetate (100-500 μM; 48 h) inhibits the proliferation of MCF-7 cells[1].
ATIC-IN-1 acetate (250 μM; 24-72 h) results the reduction of division rather than leads to cell death increase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ATIC-IN-1 acetate Related Antibodies
Molecular Weight

523.58

Formula

C23H37N7O7
Appearance

Solid

Color

White to off-white

SMILES

N=C(N)NCCC[C@H](NC(C)=O)C(N[C@H](C(N(CC)CC)=O)CC1=CC=C(C=C1)[N+]([O-])=O)=O.CC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (95.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (95.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9099 mL 9.5496 mL 19.0993 mL
5 mM 0.3820 mL 1.9099 mL 3.8199 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.69%

COA (246 KB) HNMR (314 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.9099 mL 9.5496 mL 19.0993 mL 47.7482 mL
5 mM 0.3820 mL 1.9099 mL 3.8199 mL 9.5496 mL
10 mM 0.1910 mL 0.9550 mL 1.9099 mL 4.7748 mL
15 mM 0.1273 mL 0.6366 mL 1.2733 mL 3.1832 mL
20 mM 0.0955 mL 0.4775 mL 0.9550 mL 2.3874 mL
25 mM 0.0764 mL 0.3820 mL 0.7640 mL 1.9099 mL
30 mM 0.0637 mL 0.3183 mL 0.6366 mL 1.5916 mL
40 mM 0.0477 mL 0.2387 mL 0.4775 mL 1.1937 mL
50 mM 0.0382 mL 0.1910 mL 0.3820 mL 0.9550 mL
60 mM 0.0318 mL 0.1592 mL 0.3183 mL 0.7958 mL
80 mM 0.0239 mL 0.1194 mL 0.2387 mL 0.5969 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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ATIC-IN-1 acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATIC-IN-1OthersInhibitorinhibitorinhibit

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