3067165-96-9
Chemical Structure
ATIC-IN-1 acetate
- CAS No.: 3067165-96-9
- Formula:C23H37N7O7
- Molecular Weight:523.58
IUPAC Name: (S)-2-acetamido-N-((S)-1-(diethylamino)-3-(4-nitrophenyl)-1-oxopropan-2-yl)-5-guanidinopentanamide acetate
InChIKey: DJZJDKMNBAGSBX-APTPAJQOSA-N
SMILES: N=C(N)NCCC[C@H](NC(C)=O)C(N[C@H](C(N(CC)CC)=O)CC1=CC=C(C=C1)[N+]([O-])=O)=O.CC(O)=O
Biological Activity: ATIC-IN-1 (compound 14) acetate is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM, whcich catalyzes de novo purine biosynthesis. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 acetate exhibits anti-tumor activity via reduction in cell numbers and cell division rates[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ATIC-IN-1 acetate | 99.96% | ATIC-IN-1 (compound 14) acetate is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM, whcich catalyzes de novo purine biosynthesis. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 acetate exhibits anti-tumor activity via reduction in cell numbers and cell division rates. | ||||||||||||||||||||
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