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ATIC-IN-1(compound 14) is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates.

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ATIC-IN-1 Chemical Structure

ATIC-IN-1 Chemical Structure

CAS No. : 1402453-15-9

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ATIC-IN-1 Related Antibodies

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Description

ATIC-IN-1(compound 14) is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates[1].

IC50 & Target

Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC)[1]
In Vitro

ATIC-IN-1 (10 μM, 50 μM) is a specific inhibitor, and shows nonspecific aggregate mechanism in the present of 1 mg/mL and 10 mg/mL BSA[1].
ATIC-IN-1 (100-500 μM; 48 h) inhibits the proliferation of MCF-7 cells[1].
ATIC-IN-1 (250 μM; 24-72 h) results the reduction of division rather than leads to cell death increase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ATIC-IN-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: MCF-7 cells
Concentration: 100 μM, 250 μM, 500 μM
Incubation Time: 0 h, 24 h, 48 h, and 72 h
Result: Reduced the division rate to inhibit MCF-7 proliferation at 250 μM.
Molecular Weight

463.53

Formula

C21H33N7O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N=C(N)NCCC[C@H](NC(C)=O)C(N[C@H](C(N(CC)CC)=O)CC1=CC=C(C=C1)[N+]([O-])=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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ATIC-IN-1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATIC-IN-11402453-15-9OthersInhibitorinhibitorinhibit

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ATIC-IN-1
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HY-150252
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