1402453-15-9
Chemical Structure
ATIC-IN-1
- CAS No.: 1402453-15-9
- Formula:C21H33N7O5
- Molecular Weight:463.53
IUPAC Name: (S)-2-acetamido-N-((S)-1-(diethylamino)-3-(4-nitrophenyl)-1-oxopropan-2-yl)-5-guanidinopentanamide
InChIKey: DDVRELSQBWTGRE-ROUUACIJSA-N
SMILES: N=C(N)NCCC[C@H](NC(C)=O)C(N[C@H](C(N(CC)CC)=O)CC1=CC=C(C=C1)[N+]([O-])=O)=O
Biological Activity: ATIC-IN-1(compound 14) is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates[1].
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ATIC-IN-1 | ATIC-IN-1(compound 14) is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates. | |||||||||||||||||||||
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