1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin
  3. Crolibulin

Crolibulin (Synonyms: EPC2407)

Cat. No.: HY-13603 Purity: 98.04%
Handling Instructions

Crolibulin (EPC2407) is a tubulin polymerization inhibitor, with anti-tumor activity. Crolibulin also has cardiovascular toxicity and neurotoxicity.

For research use only. We do not sell to patients.

Crolibulin Chemical Structure

Crolibulin Chemical Structure

CAS No. : 1000852-17-4

Size Price Stock Quantity
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 540 In-stock
Estimated Time of Arrival: December 31
10 mg USD 780 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2340 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Crolibulin (EPC2407) is a tubulin polymerization inhibitor, with anti-tumor activity. Crolibulin also has cardiovascular toxicity and neurotoxicity[1][2].

IC50 & Target

tubulin polymerization[1]

In Vitro

Crolibulin shows significant cytotoxic activity against HT-29 cells, with an IC50 of 0.52 μM[2].
Crolibulin is active against various experimental tumors and exhibit potent inhibition of mitosis at the G2/M stage[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

417.26

Formula

C₁₈H₁₇BrN₄O₃

CAS No.

1000852-17-4

SMILES

N#CC1=C(N)OC2=C(N)C(N)=CC=C2[[email protected]]1C3=CC(OC)=C(OC)C(Br)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (299.57 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3966 mL 11.9829 mL 23.9659 mL
5 mM 0.4793 mL 2.3966 mL 4.7932 mL
10 mM 0.2397 mL 1.1983 mL 2.3966 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

CrolibulinEPC2407EPC 2407EPC-2407Microtubule/Tubulinantineoplasticanaplasticthyroidcancercolchicine-bindingsitecellcyclearrestapoptosisInhibitorinhibitorinhibit

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Product Name:
Crolibulin
Cat. No.:
HY-13603
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