2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Mitochondrial Metabolism Microtubule/Tubulin Caspase Apoptosis
  4. ME-344

ME-344 is an Isoflavone. ME-344 increases mitochondrial ROS generation. ME-344 inhibits tubulin polymerization. ME-344 inhibits HO-1 and impacts its mitochondrial translocation. ME-344 induces Apoptosis through Caspase 3 activation. ME-344 synergizes with Vinblastine in leukemia cells. ME-344 displays anti-tumor activity against leukemia and lung tumor. ME-344 can be used in the research of lung cancer, acute myeloid leukemia, and HER2-negative breast cancer.

For research use only. We do not sell to patients.

ME-344

ME-344 Chemical Structure

CAS No. : 1374524-68-1

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Based on 1 publication(s) in Google Scholar

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ME-344 Related Antibodies

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

ME-344 is an Isoflavone. ME-344 increases mitochondrial ROS generation. ME-344 inhibits tubulin polymerization. ME-344 inhibits HO-1 and impacts its mitochondrial translocation. ME-344 induces Apoptosis through Caspase 3 activation. ME-344 synergizes with Vinblastine in leukemia cells. ME-344 displays anti-tumor activity against leukemia and lung tumor. ME-344 can be used in the research of lung cancer, acute myeloid leukemia, and HER2-negative breast cancer[1][2][3][4].

IC50 & Target[1]

Caspase 3

 

Caspase 8

 

Caspase 9

 

HO-1

 

In Vitro

ME-344 (24 h) induces apoptosis in sensitive H460 and SHP-77 human lung cancer cells via activation of Caspase 3 and subsequent cleavage of PARP[1].
ME-344 (10-10000 nM; 72 h) is cytotoxic to NB4, U937, K562, OCI-AML2, KG1a, HL-60, and TEX leukemia cell lines with IC50 values ranging from 70 to 260 nM after 72 h of treatment[2].
ME-344 (10 μM) potently inhibits tubulin polymerization in a cell-free biochemical assay[2].
ME-344 (8 h) suppresses the de novo purine biosynthesis pathway in MV4-11 AML cells after 8 h of treatment, significantly reducing levels of AICAR and IMP[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ME-344 Related Antibodies

Western Blot Analysis[1]

Cell Line: H460, SHP-77
Concentration: IC50 concentrations
Incubation Time: 24 h
Result: Induced marked cleavage of caspase 8, caspase 9, caspase 3, and PARP in H460 and SHP-77 cells. Showed higher levels of cleaved caspase 8 in H460 cells compared to SHP-77 cells. Showed higher levels of cleaved caspase 9 in SHP-77 cells compared to H460 cells.
In Vivo

ME-344 (50-100 mg/kg; i.p.; every other day; 11 days) produces dose-dependent anti-tumor efficacy in a leukemia xenograft mouse model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice (male)[2]
Dosage: 50 mg/kg; 75 mg/kg; 100 mg/kg
Administration: i.p.; every other day; 11 days
Result: Significantly reduced tumor growth relative to vehicle control at all tested doses. Produced a significant decrease in tumor weight at 100 mg/kg relative to 50 mg/kg. Showed no evidence of toxicity, as measured by stable body weight, unaltered behavior, and normal gross and histologic appearance of organs at necropsy.
Clinical Trial
Molecular Weight

348.39

Formula

C22H20O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=C2[C@H](C3=CC=C(O)C=C3)[C@H](C4=CC=C(O)C=C4)COC2=C1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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ME-344 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ME-3441374524-68-1ME344ME 344Heme Oxygenase (HO)Reactive Oxygen Species (ROS)Mitochondrial MetabolismMicrotubule/TubulinCaspaseApoptosisHeme Oxygenaselung canceracute myeloid leukemiatubulinmitochondrial complex Irough endoplasmic reticulumreactive oxygen speciescolchicine-binding siteNrf2apoptosisHO-1Inhibitorinhibitorinhibit

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