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製品番号: HY-128995

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Glycyl-Exatecan

Name: Glycyl-Exatecan
Brand: MedChemExpress
SKU: HY-128995
Availability: PreOrder

(別名: Glycyl-DX-8951; Exatecan analog 2)

Glycyl-Exatecan (G-DX-8951) is a Topoisomerase I inhibitor. Glycyl-Exatecan exhibits weaker in vitro cytotoxicity than DX-8951 (HY-13631), and can further release DX-8951 in vivo. Glycyl-Exatecan can be used in studies related to Exatecan metabolism and antitumor drug delivery.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 849479-60-3
分子式: C₂₆H₂₅FN₄O₅
分子量:492.50

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (297 KB)

Glycyl-Exatecan 構造式

CAS 番号: 849479-60-3

容量

価格（税別）

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数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Other In-stock Forms of Glycyl-Exatecan

Glycyl-Exatecan TFA

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

Topoisomerase I

Topoisomerase アイソフォーム固有の製品をすべて表示 :

体外実験

Anti-cancer

Glycyl-Exatecan (G-DX-8951) exhibits almost comparable Topoisomerase I inhibitory activity to DX-8951 in preclinical in vitro studies, while its in vitro cytotoxicity is weaker than that of DX-8951^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Glycyl-Exatecan (6 mg/kg; i.v.; single dose) (G-DX-8951) is released from DE-310 and distributed in plasma, tumor and liver after a single intravenous administration of DE-310 (5.7 mg DX-8951 equivalent/kg) to Meth A fibrosarcoma-bearing mice; Glycyl-Exatecan reaches the highest concentration at 24 h in tumor and 8 h in liver^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (5-week-old; Meth A fibrosarcoma cells subcutaneously transplanted)^[2]
Dosage:

6 mg/kg
Administration:

i.v.; single dose
Result:

Reached maximum concentrations at 5 min in plasma, tumor, and liver; showed a tissue apparent terminal t_1/2 of 3.7-11 h and released DX-8951.

Related Protocols :

化学情報

CAS 番号 849479-60-3
分子量 492.50
分子式 C₂₆H₂₅FN₄O₅
SMILES

NCC(N[C@@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C(CC1)=C62)=O
別名

Glycyl-DX-8951; Exatecan analog 2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (297 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wente MN, et al. DE-310, a macromolecular prodrug of the topoisomerase-I-inhibitor exatecan (DX-8951), in patients with operable solid tumors. Investigational new drugs. 2005 Aug;23(4):339-47. [Content Brief]

[2]. Masubuchi N. Pharmacokinetics of DE-310, a novel macromolecular carrier system for the camptothecin analog DX-8951f, in tumor-bearing mice. Pharmazie. 2004;59:374-377.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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