1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. HDAC-IN-4

HDAC-IN-4 

Cat. No.: HY-128763
Handling Instructions

HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor with pIC50s of 7.2 and 6.8 in BRET assay, respectively. Antitumoral activity.

For research use only. We do not sell to patients.

HDAC-IN-4 Chemical Structure

HDAC-IN-4 Chemical Structure

CAS No. : 1252003-13-6

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Description

HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor with pIC50s of 7.2 and 6.8 in BRET assay, respectively. Antitumoral activity[1].

IC50 & Target

pIC50: 7.2 (HDAC6), and 6.8 (HDAC10)[1]

In Vitro

HDAC-IN-4 inhibits HDAC1, HDAC2, HDAC3, HDAC8 and HDAC10 with pIC50s of 5.5, 4.6, 5.4, 5.4, 6.7 in FRET assay, respectively[1].
HDAC-IN-4 is more potent against HDAC6 than Tubastatin A, suggests that HDAC-IN-4 may be a better HDAC6 probe than Tubastatin A[1].

Molecular Weight

335.40

Formula

C₂₀H₂₁N₃O₂

CAS No.

1252003-13-6

SMILES

O=C(NO)C1=CC=C(CN2C(CN(C)CC3)=C3C4=C2C=CC=C4)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

HDAC-IN-4HDACHistone deacetylasesHDAC6HDAC10AntitumoralInhibitorinhibitorinhibit

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