SMARCA2-IN-7
SMARCA2-IN-7 (compound 12), a dual inhibitor of BRM and BRG1 (IC50 < 0.005 for both), has an anti-tumor proliferation effect that inhibits BRG1-deleted SKMEL5 tumor proliferation with a cell proliferation activity AAC50 of 13 nM in SKMEL5. The cell proliferation activity AAC50 of KRT880 in H1299 cells was 42 nM.
For research use only. We do not sell to patients.
- CAS No.: 2270879-43-9
- Formula: C11H9ClF2N4O2S
- Molecular Weight:334.73
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All SWI/SNF Complex Isoforms
More
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| SBC-5 | EC50 |
>10 μM
Compound: 12
|
Antiproliferative activity against human SBC5 cells assessed as cell growth inhibition after 6 days by celltiter-glo luminescent cell viability assay
Antiproliferative activity against human SBC5 cells assessed as cell growth inhibition after 6 days by celltiter-glo luminescent cell viability assay
|
[PMID: 30339381] |
Chemical Information
-
CAS No. 2270879-43-9
-
Molecular Weight 334.73
-
Formula C11H9ClF2N4O2S
-
SMILES
O=C(NC1=CC(C(F)F)=NS1)NC2=CC(Cl)=NC=C2CO
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SMARCA2-IN-7 Related Classifications
HY-161886 Related Classifications
Powered by Bioz