2270879-43-9
2270879-43-9
Chemical Structure
SMARCA2-IN-7
- CAS No.: 2270879-43-9
- Formula:C11H9ClF2N4O2S
- Molecular Weight:334.73
InChIKey: AVHFGSYJGSZHIC-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(C(F)F)=NS1)NC2=CC(Cl)=NC=C2CO
Biological Activity: SMARCA2-IN-7 (compound 12), a dual inhibitor of BRM and BRG1 (IC50 < 0.005 for both), has an anti-tumor proliferation effect that inhibits BRG1-deleted SKMEL5 tumor proliferation with a cell proliferation activity AAC50 of 13 nM in SKMEL5. The cell proliferation activity AAC50 of KRT880 in H1299 cells was 42 nM[1].
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SMARCA2-IN-7 | SMARCA2-IN-7 (compound 12), a dual inhibitor of BRM and BRG1 (IC50 < 0.005 for both), has an anti-tumor proliferation effect that inhibits BRG1-deleted SKMEL5 tumor proliferation with a cell proliferation activity AAC50 of 13 nM in SKMEL5. The cell proliferation activity AAC50 of KRT880 in H1299 cells was 42 nM. | |||||||||||||||||||||
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References
Keywords
