TMC-169
TMC-169 is a potent antibiotic of the Aspochalasin group that can be isolated from Aspergillus flavipes. TMC-169 exhibits anti-tumor activity against multiple cancer cells. TMC-169 can be used for the research of cancer, such as hematologic malignancies, non-small cell lung cancer, breast cancer, and glioma.
For research use only. We do not sell to patients.
- CAS No.: 242147-94-0
- Formula: C24H35NO3
- Molecular Weight:385.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
5 μM
Compound: 7, TMC-169
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Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
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[PMID: 15043404] |
TMC-169 (48 h) demonstrates broad-spectrum cytotoxic activity against NCI-H460, MCF-7, and SF-268 cells with IC50 values of 3.5, 5.0, and 9.5 μM, respectively[1].
TMC-169 shows moderate cytotoxic activity against U937, Jurkat, HL-60, WiDr, and HCT-116 tumor cell lines, with IC50 values of 0.81, 0.21, 0.68, 0.83, and 0.78 μM, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 242147-94-0
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Molecular Weight 385.54
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Formula C24H35NO3
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SMILES
O=C1N[C@@H](CC(C)C)[C@]2([H])[C@H](C)C(C)=C[C@@](/C=C(C)/CCCC(O)/C=C/3)([H])[C@]12C3=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Zhou GX, et al. Aspochalasins I, J, and K: three new cytotoxic cytochalasans of Aspergillus flavipes from the rhizosphere of Ericameria laricifolia of the Sonoran Desert. J Nat Prod. 2004 Mar;67(3):328-32. [Content Brief]
[2]. Kohno J, et al. TMC-169, a new antibiotic of the aspochalasin group produced by Aspergillus flavipes. J Antibiot (Tokyo). 1999 Jun;52(6):575-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TMC-169 Related Classifications
HY-180416 Related Classifications
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- TMC-169
- 242147-94-0
- TMC169
- TMC 169
- Antibiotic
- U937 human histiocytic lymphoma
- cytochalasan
- Jurkat human lymphoma
- tumor cell lines
- NCI-H460
- SF-268
- HCT-116 human colon carcinoma
- cancer
- WiDr human colon adenocarcinoma
- MCF-7
- HL-60 human promyelocytic leukemia
- aspochalasin group
- cytotoxic activity
- cancer cells
- Inhibitor
- inhibitor
- inhibit