242147-94-0
242147-94-0
Chemical Structure
TMC-169
- CAS No.: 242147-94-0
- Formula:C24H35NO3
- Molecular Weight:385.54
InChIKey: PBMWGTZJDVBFGK-YJEZAUDRSA-N
SMILES: O=C1N[C@@H](CC(C)C)[C@]2([H])[C@H](C)C(C)=C[C@@](/C=C(C)/CCCC(O)/C=C/3)([H])[C@]12C3=O
Biological Activity: TMC-169 is a potent antibiotic of the Aspochalasin group that can be isolated from Aspergillus flavipes. TMC-169 exhibits anti-tumor activity against multiple cancer cells. TMC-169 can be used for the research of cancer, such as hematologic malignancies, non-small cell lung cancer, breast cancer, and glioma[1][2].
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TMC-169 | TMC-169 is a potent antibiotic of the Aspochalasin group that can be isolated from Aspergillus flavipes. TMC-169 exhibits anti-tumor activity against multiple cancer cells. TMC-169 can be used for the research of cancer, such as hematologic malignancies, non-small cell lung cancer, breast cancer, and glioma. | |||||||||||||||||||||
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References
- [1]. Zhou GX, et al. Aspochalasins I, J, and K: three new cytotoxic cytochalasans of Aspergillus flavipes from the rhizosphere of Ericameria laricifolia of the Sonoran Desert. J Nat Prod. 2004 Mar;67(3):328-32. [Content Brief]
- [2]. Kohno J, et al. TMC-169, a new antibiotic of the aspochalasin group produced by Aspergillus flavipes. J Antibiot (Tokyo). 1999 Jun;52(6):575-7. [Content Brief]
Keywords
