Trastuzumab duocarmazine
Based on 1 Customer Validation
Trastuzumab duocarmazine ((vic)-Trastuzumab duocarmazine) is a HER2-targeting ADC that is recognized and cleaved by histone B in tumor cells and selectively targets tumor cells. Trastuzumab duocarmazine has anti-tumor activity and can be used in cancer research related to uterine and ovarian sarcomas.
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 1642152-40-6
- Molecular Weight:149000 (average)
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Storage:
-80°C, protect from light
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Trastuzumab duocarmazine (SYD985) (0.0001-100 μg/mL, 24 h) is lethal to both HER2- and HER2+ cells, and is 7-fold more lethal to HER2/NEU3+ cell lines with the IC50 value of 0.013 μg/mL compared to T-DM1 with the IC50 value of 0.096 μg/mL. More importantly, in HER2/NEU1+ cells, it is 54 times more potent in killing cells compared to T-DM1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1642152-40-6
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Appearance Liquid
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Molecular Weight 149000 (average)
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Color Colorless to light yellow
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SMILES
[Trastuzumab duocarmazine]
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Synonyms
(vic)-Trastuzumab duocarmazine
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Shipping
Shipping with dry ice.
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Storage
-80°C, protect from light
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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