anti-TNBC agent-6
anti-TNBC agent-6 (compound pt-3) is a potent anti-TNBC agent. anti-TNBC agent-6 shows cytotoxic activity. anti-TNBC agent-6 induces autophagy and ferroptosis. anti-TNBC agent-6 enhances intracellular ROS accumulatio. anti-TNBC agent-6 shows anti tumor activity and has the potential for the research of breast cancer.
For research use only. We do not sell to patients.
- Formula: C28H18F6N3O2PPt-
- Molecular Weight:768.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
anti-TNBC agent-6 (compound pt-3) (48 h) shows cytotoxic for MDA-MB-231, MCF-7, B16-F10, SK-OV-3, WI-38 cells[1].
anti-TNBC agent-6 (2 µM; 0, 12, 24, 36, 48 h) induce autophagy by increases the expression of Beclin-1, LC3-II in a time dependent manner in MDA-MB-231 cells[1].
anti-TNBC agent-6 (2 µM; 0, 12, 24, 36, 48 h) induces ferroptosis by decreases the expression of GPX4 in a time dependent manner[1].
anti-TNBC agent-6 (1, 2 µM) increases MDA content in MDA-MB-231 cells in a dose dependent manner[1].
anti-TNBC agent-6 (2 µM) enhances intracellular ROS accumulation and increases the labile iron pool (LIP) within cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549, A549/CDDP cells
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Concentration:0-28 µM
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Incubation Time:48 h
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Result:Showed cytotoxic activity with IC50s of 2.84, 4.12 µM for A549, A549/CDDP cells, respectively.
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Cell Line:MDA-MB-231 cells
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Concentration:2 µM
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Incubation Time:0, 12, 24, 36, 48 h
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Result:Increased the expression of Beclin-1, LC3-II in a time dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:25 g, 5 weeks, female KM mice (MDA-MB-231 xenograft model)[1]
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Dosage:10 mg/kg
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Administration:I.p.; on days 0, 3, 6, 9, 12, 15, and 18
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Result:Significantly inhibited tumor growth compared to the vehicle controls, elicited an inhibition rates of tumor growth (IRT) as high as 65.3%.
Chemical Information
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Molecular Weight 768.51
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Formula C28H18F6N3O2PPt-
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SMILES
[F-][P+5]([F-])([F-])([F-])([F-])[F-].C12=C(C=C3C4=[N](C=CC3=C2)[Pt]5([N]6=CC=CC7=C6C8=C(C=C7)C=CC=[N]85)C9=CC=CC=C49)OCO1.[+]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
anti-TNBC agent-6 Related Classifications
HY-158108 Related Classifications
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