HDAC/PSMD14-IN-1
HDAC/PSMD14-IN-1 (Compound 8B) is a thiolutin derivative. HDAC/PSMD14-IN-1 is a orally active dual-target inhibitor of PSMD14/HDAC1 (IC50 238.7 nM/141.2 nM, respectively). HDAC/PSMD14-IN-1 has good cytotoxicity against ESCC cell lines (IC50: 30-250 nM) and effectively reverses epithelial-mesenchymal transition (EMT). HDAC/PSMD14-IN-1 can induce apoptosis. HDAC/PSMD14-IN-1 has anti-tumor activity in a KYSE30 cell mouse xenograft model. HDAC/PSMD14-IN-1 can be used in anti-esophageal cancer research.
For research use only. We do not sell to patients.
- CAS No.: 3062141-62-9
- Formula: C20H24N4O3S2
- Molecular Weight:432.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HDAC1 141.2 nM (IC50) |
Chemical Information
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CAS No. 3062141-62-9
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Molecular Weight 432.56
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Formula C20H24N4O3S2
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SMILES
O=C(CCCCCCC(NC1=C2C(N(C)C1=O)=CSS2)=O)NC3=CC=CC=C3N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC/PSMD14-IN-1 Related Classifications
HY-172878 Related Classifications
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