P60-L3-VHL
Based on 1 Customer Validation
P60-L3-VHL is a PROTAC-class Foxp3 degrader. P60-L3-VHL reduced cell differentiation and Foxp3 expression in activated Treg cells in vitro and had anti-tumor activity.
(Pink: FOXP3 ligand (HY-162946); Blue: VHL ligand (HY-125845); Black: linker (HY-162947)).
For research use only. We do not sell to patients.
- Purity: 99.84%
- Formula: C135H189N33O27S3
- Molecular Weight:2802.35
-
Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Chemical Information
-
Appearance Solid
-
Molecular Weight 2802.35
-
Formula C135H189N33O27S3
-
Color White to off-white
-
SMILES
O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@@H]3C[C@H](CN3C([C@@H](NC(COCCOCCNC(CCCCCN4C=C(N=N4)CCCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@H](C(N5CCC[C@H]5C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCSC)=O)C)=O)CC6=CC=CC=C6)=O)CC7=CC=CC=C7)=O)=O)CC8=CNC9=C8C=CC=C9)=O)CCSC)=O)CCCCN)=O)=O)CC%10=CC=CC=C%10)=O)=O)CCC(N)=O)=O)CC%11=CC=CC=C%11)=O)CC(O)=O)=O)CCCNC(N)=N)=O)=O)=O)C(C)(C)C)=O)O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (35.68 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (277 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.3568 mL | 1.7842 mL | 3.5684 mL | 8.9211 mL |
| 5 mM | 0.0714 mL | 0.3568 mL | 0.7137 mL | 1.7842 mL | |
| 10 mM | 0.0357 mL | 0.1784 mL | 0.3568 mL | 0.8921 mL | |
| 15 mM | 0.0238 mL | 0.1189 mL | 0.2379 mL | 0.5947 mL | |
| 20 mM | 0.0178 mL | 0.0892 mL | 0.1784 mL | 0.4461 mL | |
| 25 mM | 0.0143 mL | 0.0714 mL | 0.1427 mL | 0.3568 mL | |
| 30 mM | 0.0119 mL | 0.0595 mL | 0.1189 mL | 0.2974 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
P60-L3-VHL Related Classifications
HY-162943 Related Classifications
Powered by Bioz