P60-L3-VHL 

P60-L3-VHL is a PROTAC-class Foxp3 degrader. P60-L3-VHL reduced cell differentiation and Foxp3 expression in activated Treg cells in vitro and had anti-tumor activity (Blue: E3 ligase ligand (HY-162945); Pink: target protein ligand (HY-162946); Black: linker (HY-162947))^[1].

2802.35

C₁₃₅H₁₈₉N₃₃O₂₇S₃

Solid

White to off-white

O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@@H]3C[C@H](CN3C([C@@H](NC(COCCOCCNC(CCCCCN4C=C(N=N4)CCCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@H](C(N5CCC[C@H]5C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCSC)=O)C)=O)CC6=CC=CC=C6)=O)CC7=CC=CC=C7)=O)=O)CC8=CNC9=C8C=CC=C9)=O)CCSC)=O)CCCCN)=O)=O)CC%10=CC=CC=C%10)=O)=O)CCC(N)=O)=O)CC%11=CC=CC=C%11)=O)CC(O)=O)=O)CCCNC(N)=N)=O)=O)=O)C(C)(C)C)=O)O

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Yang B, et al. Discovery of a proteolysis targeting chimera (PROTAC) as a potent regulator of FOXP3[J]. Bioorganic & Medicinal Chemistry Letters, 2024: 129945.  [Content Brief]