2-(2-(2-(6-Azidohexanamido)ethoxy)ethoxy)acetic acid

Cat. No.: HY-162947 Purity: 99.75%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

2-(2-(2-(6-Azidohexanamido)ethoxy)ethoxy)acetic acid is a PROTACT linker and can be used for synthesis of P60-L3-VHL (HY-162943). 2-(2-(2-(6-Azidohexanamido)ethoxy)ethoxy)acetic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

2-(2-(2-(6-Azidohexanamido)ethoxy)ethoxy)acetic acid Chemical Structure

CAS No. : 3036674-82-2

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Purity & Documentation
References
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Description

Molecular Weight

302.33

Formula

C₁₂H₂₂N₄O₅

CAS No.

3036674-82-2

Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(O)COCCOCCNC(CCCCCN=[N+]=[N-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (165.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3076 mL	16.5382 mL	33.0764 mL
5 mM	0.6615 mL	3.3076 mL	6.6153 mL
10 mM	0.3308 mL	1.6538 mL	3.3076 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.75%

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Data Sheet (266 KB) SDS (252 KB)

COA (240 KB) HNMR (257 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Yang B, et al. Discovery of a proteolysis targeting chimera (PROTAC) as a potent regulator of FOXP3. Bioorg Med Chem Lett. 2024 Nov 1;112:129945. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3076 mL	16.5382 mL	33.0764 mL	82.6911 mL
	5 mM	0.6615 mL	3.3076 mL	6.6153 mL	16.5382 mL
	10 mM	0.3308 mL	1.6538 mL	3.3076 mL	8.2691 mL
	15 mM	0.2205 mL	1.1025 mL	2.2051 mL	5.5127 mL
	20 mM	0.1654 mL	0.8269 mL	1.6538 mL	4.1346 mL
	25 mM	0.1323 mL	0.6615 mL	1.3231 mL	3.3076 mL
	30 mM	0.1103 mL	0.5513 mL	1.1025 mL	2.7564 mL
	40 mM	0.0827 mL	0.4135 mL	0.8269 mL	2.0673 mL
	50 mM	0.0662 mL	0.3308 mL	0.6615 mL	1.6538 mL
	60 mM	0.0551 mL	0.2756 mL	0.5513 mL	1.3782 mL
	80 mM	0.0413 mL	0.2067 mL	0.4135 mL	1.0336 mL
	100 mM	0.0331 mL	0.1654 mL	0.3308 mL	0.8269 mL