PD-L1-IN-5
PD-L1-IN-5 (X22) is an orally active PD-L1 inhibitor, with the IC50 value of 785.6 nM. PD-L1-IN-5 has anti-tumor activity in vivo.
For research use only. We do not sell to patients.
- CAS No.: 2597056-85-2
- Formula: C40H44ClFN4O8
- Molecular Weight:763.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PD-L1-IN-5 (X22) (0-150 μM, 12 h) has no obvious cytotoxic effect on MC38 and CT26 cells in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pharmacokinetic Analysis in SD rats and C57blo/6 mice[1]
| Animal model | Route | Dose (mg/kg) | t1/2 (h) | Tmax (h) | Cmax (ng/mL) | AUC0-t (ng·h/mL) | CL (mL/h/kg) | F (%) |
| SD rat | p.o. | 45 | 4.3 | 4.00 | 49.8 | 405.6 | / | 3.4 |
| C57blo/6 mice | p.o. | 10 | 1.6 | 0.7 | 255.7 | 315.6 | / | 11.5 |