1. Protein Tyrosine Kinase/RTK
    Apoptosis
  2. VEGFR
    FGFR
    Apoptosis
  3. R1530

R1530 

Cat. No.: HY-13737 Purity: 99.06%
Handling Instructions

R1530 is a highly potent, orally bioavailable, dual-acting mitosis/angiogenesis inhibitor, with antitumor and anti-angiogenic activity. R1530 is a multikinase inhibitor which binds to 31 kinases with Kds of <500 nM. R1530 inhibits VGFR2 and FGFR1 with IC50s of 10 nM and 28 nM, respectively.

For research use only. We do not sell to patients.

R1530 Chemical Structure

R1530 Chemical Structure

CAS No. : 882531-87-5

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Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

R1530 is a highly potent, orally bioavailable, dual-acting mitosis/angiogenesis inhibitor, with antitumor and anti-angiogenic activity. R1530 is a multikinase inhibitor which binds to 31 kinases with Kds of <500 nM. R1530 inhibits VGFR2 and FGFR1 with IC50s of 10 nM and 28 nM, respectively[1][2][3].

IC50 & Target[1]

KDR

10 nM (IC50)

FGFR1

28 nM (IC50)

Molecular Weight

356.78

Formula

C₁₈H₁₄ClFN₄O

CAS No.

882531-87-5

SMILES

CC(NN1)=C2C1=NC3=CC(OC)=C(F)C=C3C(C4=CC=CC=C4Cl)=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 2 mg/mL (5.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8028 mL 14.0142 mL 28.0285 mL
5 mM 0.5606 mL 2.8028 mL 5.6057 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.06%

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Keywords:

R1530R 1530R-1530VEGFRFGFRApoptosisVascular endothelial growth factor receptorFibroblast growth factor receptormitoticmitosisangiogenesisantitumorantiproliferativeInhibitorinhibitorinhibit

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Product Name:
R1530
Cat. No.:
HY-13737
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