2. Cell Cycle/DNA Damage Epigenetics
  3. Aurora Kinase
  4. Aurora kinase-IN-10

Aurora kinase-IN-10 is an Aurora kinase inhibitor. Aurora kinase-IN-10 exhibits IC50 values of 5.94 nM and 86.06 nM against Aurora A and Aurora B, respectively. Aurora kinase-IN-10 has anti-tumor activity and can be used in the research of tumors such as triple-negative breast cancer.

For research use only. We do not sell to patients.

Aurora kinase-IN-10

Aurora kinase-IN-10 Chemical Structure

CAS No. : 3053885-69-8

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Aurora kinase-IN-10 Related Antibodies

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Description

Aurora kinase-IN-10 is an Aurora kinase inhibitor. Aurora kinase-IN-10 exhibits IC50 values of 5.94 nM and 86.06 nM against Aurora A and Aurora B, respectively. Aurora kinase-IN-10 has anti-tumor activity and can be used in the research of tumors such as triple-negative breast cancer[1].

IC50 & Target[1]

Aurora A

5.94 nM (IC50)

Aurora B

86.06 nM (IC50)

In Vitro

Aurora kinase-IN-10 (48 h) inhibits the proliferation of MDA-MB-231, A549, PC9 and LO2 cells, with IC50 values of 1.49, 19.44, 6.57 and 48.11 μM, respectively[1].
Aurora kinase-IN-10 has a half-life of 126.6 min in rat liver microsomes and approximately 18.3 h in rat plasma[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aurora kinase-IN-10 Related Antibodies
Parmacokinetics
Species Dose Route Cmax AUC0-t AUC0-∞ Vz T1/2 CL MRT0-t F
Rat[1] 5 mg/kg i.v. 3427.29 ng/mL 6674.48 ng·h/mL 6751.40 ng·h/mL 69.84 L/kg 4.15 h 639.92 mL/h/kg 6.55 h /
Rat[1] 10 mg/kg p.o. 7511.55 ng/mL 6742.80 ng·h/mL 7832.47 ng·h/mL 177.37 L/kg 5.57 h 1184.17 mL/h/kg 7.18 h 58 %
In Vivo

Aurora kinase-IN-10 (Compound 4q) (15 mg/kg; i.p.; once every 2 days; 20 days) exhibits potent in vivo anti-tumor efficacy in the MDA-MB-231 xenograft mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (female, 4-5 weeks old, 19-22 g, MDA-MB-231 xenograft model)[1]
Dosage: 15 mg/kg
Administration: i.p.; every two days; 20 consecutive days
Result: Achieved a tumor growth inhibition rate of 56.7%.
Showed no significant body weight change compared to the vehicle group.
Produced no significant histopathological alterations in major organs (heart, liver, spleen, lung, kidney) on hematoxylin-eosin staining.
Molecular Weight

471.53

Formula

C26H26FN7O
CAS No.
SMILES

CC(N1CCN(CC1)C2=CC=C3C(N=C(N=C3NC4=NNC(C)=C4)/C=C/C5=CC=C(C=C5)F)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Aurora kinase-IN-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aurora kinase-IN-103053885-69-8Aurora KinaseLO2 cellsPC9 cellsMDA-MB-231 cellsAurora kinase Aliver microsomesAurora kinase Bnon-small cell lung cancerA549 cellstriple-negative breast cancerInhibitorinhibitorinhibit

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