1. PROTAC
    Apoptosis
    Metabolic Enzyme/Protease
  2. PROTAC
    MDM-2/p53
    E1/E2/E3 Enzyme
  3. PROTAC MDM2 Degrader-2

PROTAC MDM2 Degrader-2 

Cat. No.: HY-128841 Purity: 98.50%
Handling Instructions

PROTAC MDM2 Degrader-2 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-2 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase.

For research use only. We do not sell to patients.

PROTAC MDM2 Degrader-2 Chemical Structure

PROTAC MDM2 Degrader-2 Chemical Structure

CAS No. : 2249944-99-6

Size Price Stock Quantity
10 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
25 mg USD 3300 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

View All PROTAC Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PROTAC MDM2 Degrader-2 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-2 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase[1].

IC50 & Target

MDM2

 

Molecular Weight

1391.22

Formula

C₇₀H₇₆Cl₄N₁₀O₁₂

CAS No.

2249944-99-6

SMILES

O=C(N1CC(N(CC(NCCOCCOCCNC(CN2C(CN(C(N3[[email protected]@H](C4=CC=C(Cl)C=C4)[[email protected]@H](C5=CC=C(Cl)C=C5)N=C3C6=C(C=C(OC)C=C6)OC(C)C)=O)CC2)=O)=O)=O)CC1)=O)N7[[email protected]@H](C8=CC=C(Cl)C=C8)[[email protected]@H](C9=CC=C(Cl)C=C9)N=C7C%10=C(C=C(OC)C=C%10)OC(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (35.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7188 mL 3.5940 mL 7.1879 mL
5 mM 0.1438 mL 0.7188 mL 1.4376 mL
10 mM 0.0719 mL 0.3594 mL 0.7188 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (1.80 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.80 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PROTAC MDM2 Degrader-2PROTACMDM-2/p53E1/E2/E3 EnzymeProteolysis-targeting chimeraE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PROTAC MDM2 Degrader-2
Cat. No.:
HY-128841
Quantity:
MCE Japan Authorized Agent: