TQFL13
TQFL13 is derivative of Thymoquinone (TQ) (HY-D0803) with potent anti-breast cancer activity. TQFL13 exhibits higher cytotoxicity against breast cancer cells (BT549, MDA-MB-231, 4T1). TQFL13 increases apoptosis and blocks the cell cycle at S and G2/G1 phases in breast cancer cells. TQFL13 shows dose-dependent anti-tumor efficacy in mouse breast cancer allograft model. TQFL13 can be used for the study of breast cancer.
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- CAS No.: 2822560-46-1
- 화학식: C20H23NO5
- 분자량:357.40
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
TQFL13 (0-160 μM, 24 h) exerts cytotoxic activity against BT549, MDA-MB-231, 4T1 breast cancer cells and normal MCF-10A cells, with IC50 values of 23.80 μM, 37.55 μM, 17.59 μM, and > 100 μM, respectively[1].
TQFL13 (48 h) displays anti-viability activity against BT549, MDA-MB-231, 4T1 breast cancer cells and normal MCF-10A cells, with IC50 values of 12.35 μM, 12.14 μM, 12.21 μM, and >100 μM, respectively[1].
TQFL13 (0-20 μM, 24 h) increases apoptosis in 4 T1 cells and blocks the cell cycle at S and G2/G1 phases in BT549 and MDA-MB-231 breast cancer cells[1].
TQFL13 (2.5-5 μM, 0-54 h) inhibits 4 T1 cell growth, migration, and invasion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:4 T1 and MDA-MB-231 breast cancer cells
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Concentration:0, 5, 10, 20 μM
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Incubation Time:24 h
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Result:Induced the apoptosis.
Reduced the full-length PARP and BCL-2.
Increased the level of BAX.
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Cell Line:BT549 and MDA-MB-231 breast cancer cells
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Concentration:0, 5, 10, 20 μM
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Incubation Time:24 h
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Result:Blocked the cell cycle at S and G2/G1 phases.
Downregulated the level of CyclinB1, CyclinD1and p53.
Upregulated the level of phosphorylated p53 (ser15).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4T1 mouse breast cancer cells were injected into the fourth mammary fat pads of female BALB/c mice to construct a breast cancer lung metastasis model [1]
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Dosage:3.75, 7.5, 15 mg/kg
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Administration:i.p., starts 4 days after 4T1 cell inoculation into mammary fat pads, continues until day 30
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Result:Showed dose-dependent anti-tumor efficacy.
Showed no significant changes in body weight.
Altered the morphology of breast tumor cells.
Exerted anti-tumor activity by regulating cell apoptosis and cell cycle signaling pathways.
Chemical Information
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CAS No. 2822560-46-1
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분자량 357.40
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화학식 C20H23NO5
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SMILES
COC1=CC=C(C(OC)=C1OC)/C=N/C2=C(C(C=C(C2=O)C(C)C)=O)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TQFL13 Related Classifications
HY-175846 Related Classifications
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