AT9283 hydrochloride
Based on 9 publication(s) in Google Scholar
AT9283 hydrochloride is a multi-targeted kinase inhibitor with anti-tumor activity. AT9283 hydrochloride has been found to effectively inhibit Aurora A and Aurora B kinases, thereby affecting cell proliferation and survival. AT9283 hydrochloride can also inhibit several other kinases, including JAK2 and Abl (T315I).
For research use only. We do not sell to patients.
- CAS No.: 896466-61-8
- Formula: C19H24ClN7O2
- Molecular Weight:417.89
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) AT9283 hydrochloride
More- J Adv Res. 2024 Feb:56:1-14. [Abstract]
- Sci Transl Med. 2018 Jul 18;10(450):eaaq1093. [Abstract]
- PLoS Pathog. 2022 Jun 13;18(6):e1010620. [Abstract]
- Cancers (Basel). 2022 Mar 19;14(6):1575. [Abstract]
- Front Oncol. 2021 Jun 18:11:656608. [Abstract]
- PLoS One. 2024 Nov 1;19(11):e0308647. [Abstract]
- University of Washington. 2025.
- bioRxiv. 2025 February 21.
- Patent. US20180263995A1.
All Aurora Kinase Isoforms
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Biological Activity
Chemical Information
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CAS No. 896466-61-8
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Molecular Weight 417.89
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Formula C19H24ClN7O2
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SMILES
O=C(NC1CC1)NC2=CNN=C2C3=NC(C=C4)=C(C=C4CN5CCOCC5)N3.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (9)
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Journal Impact Factor
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Most Recent
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J Adv Res
Strain specificity of lactobacilli with promoted colonization by galactooligosaccharides administration in protecting intestinal barriers during Salmonella infection. [Abstract]2024 Feb:56:1-14. PMID: 36894120 -
Sci Transl Med
PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells. [Abstract]2018 Jul 18;10(450):eaaq1093. PMID: 30021885 -
PLoS Pathog
Bile acids promote the caveolae-associated entry of swine acute diarrhea syndrome coronavirus in porcine intestinal enteroids. [Abstract]2022 Jun 13;18(6):e1010620. PMID: 35696443 -
Cancers (Basel)
Identification of New Vulnerabilities in Conjunctival Melanoma Using Image-Based High Content Drug Screening. [Abstract]2022 Mar 19;14(6):1575. PMID: 35326726 -
Front Oncol
GEFT Inhibits Autophagy and Apoptosis in Rhabdomyosarcoma via Activation of the Rac1/Cdc42-mTOR Signaling Pathway. [Abstract]2021 Jun 18:11:656608. PMID: 34221974 -
PLoS One
A novel small molecule screening assay using normal human chondrocytes toward osteoarthritis drug discovery. [Abstract]2024 Nov 1;19(11):e0308647. PMID: 39485774 -
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Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AT9283 hydrochloride Related Classifications
HY-10057 Related Classifications
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