Anti-inflammatory agent 80
Anti-inflammatory agent 80 (Compound 2/2f) is an anti-inflammatory agent and has anti-tumor activity. Anti-inflammatory agent 80 can be isolated fromCynanchum limprichtiiSchltr.
For research use only. We do not sell to patients.
- CAS No.: 2128277-55-2
- Formula: C40H60O13
- Molecular Weight:748.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Anti-inflammatory agent 80 (Compound 2) is cytotoxic to the human cancer cell line HL60[1].
Anti-inflammatory agent 80 (Compound 2f) (100 μM; 1 h) significantly inhibits LPS-induced iNOS protein expression in RAW264.7 cells [2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:RAW264.7 cells
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Concentration:100 μM
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Incubation Time:1 h
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Result:Significantly inhibited LPS-induced iNOS protein expression.
Chemical Information
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CAS No. 2128277-55-2
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Molecular Weight 748.90
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Formula C40H60O13
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SMILES
C[C@]12[C@]([C@](CO2)([H])O3)([H])[C@]4(CO1)C3=C(CC=C(C5)[C@@]6(CC[C@@H]5O[C@H](O[C@@H]7C)C[C@H]([C@@H]7O[C@H](O[C@@H]8C)C[C@@H]([C@@H]8O[C@H](O[C@H]9C)C[C@H]([C@H]9O)OC)O)O)C)[C@]6([H])CC4
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-inflammatory agent 80 Related Classifications
HY-N12817 Related Classifications
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