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SEN461

SEN461 is a potent and orally active Wnt pathway inhibitor. SEN461 shows effective anti-tumor activity and can be used for GBM research.

For research use only. We do not sell to patients.

CAS No.: 1287727-28-9
Formula: C₂₅H₃₄N₄O₆
Molecular Weight:486.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

SEN461 Chemical Structure

CAS No.: 1287727-28-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

SEN461 is a potent and orally active Wnt pathway inhibitor. SEN461 shows effective anti-tumor activity and can be used for GBM research^[1].

All Wnt Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
DLD-1	IC₅₀	0.71 μM Compound: 33, SEN461	Growth inhibition of human DLD1 cells after 14 to 21 days by soft agar assay Growth inhibition of human DLD1 cells after 14 to 21 days by soft agar assay	[PMID: 25847770]
NCI-N87	IC₅₀	1.8 μM Compound: 33, SEN461	Growth inhibition of human NCI-N87 cells after 14 to 21 days by soft agar assay Growth inhibition of human NCI-N87 cells after 14 to 21 days by soft agar assay	[PMID: 25847770]

Chemical Information

CAS No. 1287727-28-9
Molecular Weight 486.56
Formula C₂₅H₃₄N₄O₆
SMILES

O=C(N(C1=C(C2=O)C=C(C=C1)OC)C)N2C[C@H]3CC[C@@H](CC3)C(N4CCN(CC4)C(COC)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nencini, A, et al. Structure–activity relationship and properties optimization of a series of Quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway. European Journal of Medicinal Chemistry, 95, 526–545. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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