2. Metabolic Enzyme/Protease Apoptosis
  3. TrxR Apoptosis
  4. LW-216

LW-216 is a TrxR1 inhibitor that induces Apoptosis. LW-216 has anti-tumor activity.

For research use only. We do not sell to patients.

LW-216

LW-216 Chemical Structure

CAS No. : 2146090-18-6

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LW-216 Related Antibodies

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Description

LW-216 is a TrxR1 inhibitor that induces Apoptosis. LW-216 has anti-tumor activity[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
1.1 μM
Compound: 18l
Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 28987604]
B16 IC50
3.21 μM
Compound: 18l
Cytotoxicity in mouse B16 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity in mouse B16 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 28987604]
HepG2 IC50
4.66 μM
Compound: 18l
Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 28987604]
MCF7 IC50
1.89 μM
Compound: 18l
Cytotoxicity in human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity in human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 28987604]
In Vitro

LW-216 (5-25 μM, 24 h) selectively downregulates TrxR1 protein levels and induce apoptosis in NCI-H460 and A549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LW-216 Related Antibodies

Western Blot Analysis[1]

Cell Line: NCI-H460, A549
Concentration: 5, 15, 25 μM
Incubation Time: 24 h
Result: Reduced TrxR1 expression in both cell lines.
Decreased the protein level of Bcl-2, PARP1 and Caspase-9, while increased Bax.
In Vivo

LW-216 (8 mg/kg, intravenously, once every two days for 18 days) inhibits tumor growth of NCI-H460 cells in a xenograft mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NCI-H460 cells in a xenograft mice model[1]
Dosage: 8 mg/kg, once every two days for 18 days
Administration: i.v.
Result: Reduced bioluminescence intensity.
Increased the expression of apoptosis-related proteins Bax and Cleaved Caspase-3, while decreasing the expression of the proliferation-related protein Ki67.
Molecular Weight

485.57

Formula

C30H31NO5
CAS No.
SMILES

O=C1C=C(C2=CC=CC=C2)OC3=C(C(OCC4=CC=CC=C4)=CC(O)=C13)OCCCCN5CCCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LW-216 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LW-2162146090-18-6LW216LW 216TrxRApoptosisThioredoxin ReductaseInhibitorNCI-H460A549anti-tumorinhibitorinhibit

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