HPK1-IN-52
HPK1-IN-52 is a potent and orally active hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 value of 10.4 nM. HPK1-IN-52 exhibits anti-tumor activities.
For research use only. We do not sell to patients.
- CAS No.: 2994298-66-5
- Formula: C31H30F2N6O2
- Molecular Weight:556.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All MAP4K Isoforms
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Biological Activity
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HPK1 10.4 nM (IC50) |
MAP4K2 448 nM (IC50) |
GLK/MAP4K3 85 nM (IC50) |
MAP4K4 665 nM (IC50) |
MAP4K5 104 nM (IC50) |
MAP4K6 168 nM (IC50) |
HPK1-IN-52's plasma clearance significantly improved (Clp = 46 mL/min/kg) in mice, and its oral exposure dramatically increased (AUC(0–24h) = 4139 h ng/mL). In addition, HPK1-IN-52 exhibits lower in vivo clearance (Clp = 67 mL/min/kg) and higher oral exposure (AUC(0–24h) = 2013 h ng/mL) in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c mice injected with CT26 cells[1]
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Dosage:30 mg/kg
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Administration:po; twice daily; for two weeks
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Result:Exhibited moderate tumor-growth inhibition.
Chemical Information
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CAS No. 2994298-66-5
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Molecular Weight 556.61
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Formula C31H30F2N6O2
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SMILES
O=C1NC=CC2=C1C(NC3=NC(CN4C[C@@H](F)CC4)=C(C5CCOCC5)C=C3)=CC=C2C6=CN=C7C=C(F)C=CN76
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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