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Cat. No.: HY-14716

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CCT239065

CCT239065 is an orally available, effective inhibitor of the mutant protein kinase ^V600EBRAF (RAF) with anti-tumor activity. CCT239065 inhibits downstream signaling of ^V600EBRAF in cancer cells, blocking DNA synthesis and suppressing proliferation.

For research use only. We do not sell to patients.

CAS No.: 1163719-51-4
Formula: C₂₉H₂₉N₇O₃S
Molecular Weight:555.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

CCT239065 Chemical Structure

CAS No.: 1163719-51-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

All Raf Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
WM 266-4	GI₅₀	0.001 μM Compound: 1t	Growth inhibition of human WM266.4 cells expressing BRAF V600E mutant after 5 days by SRB assay Growth inhibition of human WM266.4 cells expressing BRAF V600E mutant after 5 days by SRB assay	[PMID: 20597484]

Chemical Information

CAS No. 1163719-51-4
Molecular Weight 555.65
Formula C₂₉H₂₉N₇O₃S
SMILES

O=C1C=NC2=C(N1)N=CC=C2OC3=CC=C(C(SC)=C3)NC(NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Steven Whittaker, et al. A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of V600EBRAF. Cancer Res. 2010 Oct 15;70(20):8036-44. [Content Brief]

[2]. James A McCubrey, et al. Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance. Oncotarget. 2012 Oct;3(10):1068-111. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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CCT239065

All DNA/RNA Synthesis Isoforms

All Raf Isoforms