2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. CYPMPO

CYPMPO is a spin-trapping reagent. CYPMPO, a cyclic DEPMPO-type nitrone, is evaluated for spin-trapping capabilities toward hydroxyl and superoxide radicals. anti-oxidant and anti-tumor activity.

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CYPMPO Chemical Structure

CYPMPO Chemical Structure

CAS No. : 934182-09-9

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Based on 1 publication(s) in Google Scholar

CYPMPO Related Antibodies

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Description

CYPMPO is a spin-trapping reagent. CYPMPO, a cyclic DEPMPO-type nitrone, is evaluated for spin-trapping capabilities toward hydroxyl and superoxide radicals. anti-oxidant and anti-tumor activity[1].

In Vitro

DMPO is often used as a spin trapping agent to detect oxygen-centered radicals. CYPMPO has a larger reaction rate constant with superoxide anion than DMPO and the superoxide adduct of CYPMPO is more stable than that of DMPO. CYPMPO (2.5 mM) acts as a spin-trap agent[2].
CYPMPO, a spin-trap, a cyclic DEPMPO-like nitrone trap, may provide new free radical information when used with mitochondria. CYPMPO has the preferential quality of having minimal mitochondrial toxicity at concentrations required for radical detection[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CYPMPO Related Antibodies
Molecular Weight

247.23

Formula

C10H18NO4P
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1(P2(OCC(C)(C)CO2)=O)[N+]([O-])=CCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : 25 mg/mL (101.12 mM; Need ultrasonic and warming)

Ethanol : 25 mg/mL (101.12 mM; Need ultrasonic and warming)

DMSO : 20 mg/mL (80.90 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0448 mL 20.2241 mL 40.4482 mL
5 mM 0.8090 mL 4.0448 mL 8.0896 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (254 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMF / Ethanol 1 mM 4.0448 mL 20.2241 mL 40.4482 mL 101.1204 mL
5 mM 0.8090 mL 4.0448 mL 8.0896 mL 20.2241 mL
10 mM 0.4045 mL 2.0224 mL 4.0448 mL 10.1120 mL
15 mM 0.2697 mL 1.3483 mL 2.6965 mL 6.7414 mL
20 mM 0.2022 mL 1.0112 mL 2.0224 mL 5.0560 mL
25 mM 0.1618 mL 0.8090 mL 1.6179 mL 4.0448 mL
30 mM 0.1348 mL 0.6741 mL 1.3483 mL 3.3707 mL
40 mM 0.1011 mL 0.5056 mL 1.0112 mL 2.5280 mL
50 mM 0.0809 mL 0.4045 mL 0.8090 mL 2.0224 mL
60 mM 0.0674 mL 0.3371 mL 0.6741 mL 1.6853 mL
80 mM 0.0506 mL 0.2528 mL 0.5056 mL 1.2640 mL
DMF / Ethanol 100 mM 0.0404 mL 0.2022 mL 0.4045 mL 1.0112 mL
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CYPMPO Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYPMPO934182-09-9Reactive Oxygen Speciesspin-trappinghydroxylsuperoxideradicalsSpintrapelectronresonancespectrometryfreeradicalInhibitorinhibitorinhibit

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