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Ragifilimab

(Synonyms: INCAGN-1876)
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Ragifilimab (INCAGN-1876) is an agonist monoclonal antibody targeting the glucocorticoid-induced TNFR-related protein (GITR). Ragifilimab binds to and activates GITR on T cells, which stimulates the immune system to enhance its anti-tumor activity. Ragifilimab can be used for advanced or metastatic solid tumors research.

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  • Pureté: 99.32%
  • CAS No.: 2207590-51-8
  • Masse moléculaire:146.46 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Ragifilimab
  • Experimental Validation Results for Ragifilimab
  • Experimental Validation Results for Ragifilimab
  • Ragifilimab Chemical Structure
    Ragifilimab Chemical Structure
CAS No.: 2207590-51-8
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609-228-6898
[email protected] [email protected]
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized GITR Protein, Human (HEK293, hFc, HY-P70683) can bind Ragifilimab. The EC50 for this effect is 8.923 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 Jurkat cells with Ragifilimab (HY-P99812, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Ragifilimab Chemical Structure
    1/16
  • Ragifilimab
  • Immobilized GITR Protein, Human (HEK293, hFc, HY-P70683) can bind Ragifilimab. The EC50 for this effect is 8.923 ng/mL.
  • Flow cytometric analysis of 1X106 Jurkat cells with Ragifilimab (HY-P99812, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).