TNFRSF18 - TNF receptor superfamily member 18 Gene

Also Known as AITR; GITR; CD357; GITR-D; ENERGEN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8784

About TNFRSF18

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,203,508-1,206,592 (from NCBI)

This gene has 4 transcripts (splice variants), 562 orthologues and 21 paralogues. Biased expression in skin (RPKM 4.0), appendix (RPKM 1.0) and 12 other tissues.

Summary

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]

TNFRSF18 Products (3)

mRNA	Protein	Name
NM_004195.3	NP_004186.1	tumor necrosis factor receptor superfamily member 18 isoform 1 precursor
NM_148901.2	NP_683699.1	tumor necrosis factor receptor superfamily member 18 isoform 2 precursor
NM_148902.2	NP_683700.1	tumor necrosis factor receptor superfamily member 18 isoform 3 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18040044	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	23892569	GOA
involved in positive regulation of leukocyte migration	IMP IMP: Inferred from mutant phenotype	23892569	GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein	IMP IMP: Inferred from mutant phenotype	23892569	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tumor necrosis factor receptor superfamily member 18	TNF receptor superfamily activation-inducible protein

TNFRSF18 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TNFRSF18	Q9Y5U5	TNFSF18	Homo sapiens	Q9UNG2	SPR	18378892

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNFRSF18 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70683	GITR Protein, Human (HEK293, hFc)	Q9Y5U5 (Q26-E161)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70822	GITR Protein, Human (T45A, HEK293, mFc)	Q9Y5U5 (Q26-E161, T45A)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73076	GITR Protein, Human (HEK293, His)	Q9Y5U5 (Q26-E161)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75166	GITR Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q9Y5U5 (Q26-E161)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78137	GITR Protein, Human (Biotinylated, HEK293, His-Avi)	Q9Y5U5 (Q26-E161)	≥ 95%, as determined by Bis-Tris PAGE.

TNFRSF18 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81588	GITR Antibody (YA1333)	FC, ELISA	Human
HY-P84896	TNFRSF18 Antibody (YA4593)	IHC-P, FC, ELISA	Human
HY-P84896A	TNFRSF18 Antibody (YA4593)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked	IPEX X-Linked Autoimmunity-Allergic Dysregulation Syndrome Xlaad Diarrhea, Polyendocrinopathy, Fatal Infection Syndrome, X-Linked Ipex Syndrome Insulin-Dependent Diabetes Mellitus Secretory Diarrhea Syndrome Iddm-Secretory Diarrhea Syndrome Dmsd Autoimmunity-Immunodeficiency Syndrome, X-Linked Enteropathy, Autoimmune, With Hemolytic Anemia And Polyendocrinopathy Xpid Diabetes Mellitus, Congenital Insulin-Dependent, With Fatal Secretory Diarrhea Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome Polyendocrinopathy, Immune Dysfunction, And Diarrhea, X-Linked Autoimmune Enteropathy Type 1 Immunodeficiency, Polyendocrinopathy, And Enteropathy, X-Linked Immunodeficiency, Polyendocrinopathy, And Enteropathy, X-Linked, Formerly Immunodeficiency, Polyendocrinopathy, Enteropathy X-Linked Syndrome Immunodysregulation, Polyendocrinopathy And Enteropathy X-Linked Autoimmunity-Immunodeficiency Syndrome X-Linked Iddm Secretory Diarrhea Syndrome Polyendocrinopathy, Immune Dysfunction And Diarrhea X-Linked Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome Immunodeficiency Polyendocrinopathy, Enteropathy, X-Linked Syndrome X-Linked Autoimmunity-Immunodeficiency Syndrome Immunodeficiency, Polyendocrinopathy, And Enteropathy X-Linked Syndrome X-Linked Syndrome Of Polyendocrinopathy, Immune Dysfunction, And Diarrhea
Diverticulitis
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity	Cd25 Deficiency Immunodeficiency Due To Cd25 Deficiency IMD41 Interleukin 2 Receptor, Alpha, Deficiency Of Il2ra Deficiency Immunodeficiency 41 Interleukin-2 Receptor Alpha Chain Deficiency Interleukin 2 Receptor Alpha Deficiency Interleukin-2 Receptor, Alpha Chain, Deficiency Of Immunodeficiency, Type 41 With Lymphoproliferation And Autoimmunity
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Dermatitis, Atopic, 7	ATOD7 Dermatitis, Atopic, Susceptibility To, 7 Atopic Dermatitis 7 Dermatitis, Atopic 7
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Parotid Gland Adenoid Cystic Carcinoma	Adenoid Cystic Carcinoma Of Parotid Gland
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14808	TNFRSF18 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17934	Tnfrsf18 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24404	Tnfrsf18 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991404	AMG-228	Inhibitor	/	Unkown
HY-P991464	IBI37G5	Inhibitor	/	Unkown
HY-P992354	FPA154		/	Unkown
HY-P992395	JNJ-64164711		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TNFRSF18	MGD	MGI:894675
Macaca mulatta	TNFRSF18	VGNC	VGNC:78587
Rattus norvegicus	TNFRSF18	RGD	RGD:1565872
Canis familiaris	TNFRSF18	VGNC	VGNC:47660
Felis catus	TNFRSF18	VGNC	VGNC:66406
Bos taurus	TNFRSF18	VGNC	VGNC:36163
Others	TNFRSF18	NCBI