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Cat. No.: HY-P992354

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FPA154

(Synonyms: INBRX-110)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

FPA154 is a human monoclonal antibody against TNFRSF18/GITR/CD357. FPA154 activates NF-κB via the GITR pathway. FPA154 can be used in solid tumor research. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

FPA154 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target^[1]

GITR

All TNF Receptor Isoforms :

All NF-κB Isoforms :

In Vitro

FPA154 can potently exert antibody-dependent cell-mediated cytotoxicity against regulatory T cells that highly express GITR^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gene ID

8784 [NCBI]

Accession

Q9Y5U5

Target

TNFRSF18/GITR/CD357

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Application

ELISA, FACS, Functional assay

Chemical Information

Synonyms

INBRX-110
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Appl Radiat Isot

[225Ac]Ac-Macropa-PEG4-FPA150 enables targeted alpha therapy of B7-H4-Expressing tumors. [Abstract]

2026 Jun 26:236:112778. PMID: 42365835

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Susannah D. Barbee, et al. Abstract 613: Development of FPA154, a novel tetravalent anti-GITR antibody, for the treatment of solid tumors. Cancer Res 1 July 2017; 77 (13_Supplement): 613.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Publications (1)
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

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CAS No.:
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Quantity:

FPA154

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)

Publications Citing Use of MedChemExpress (MCE) FPA154

All TNF Receptor Isoforms

All NF-κB Isoforms