38 Results for "

gitr

" in MedChemExpress (MCE) Product Catalog:
Products (38)

38 Results for "gitr" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P99812
CAS No.: 2207590-51-8
Synonyms: INCAGN-1876

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

Ragifilimab (INCAGN-1876) is an agonist monoclonal antibody targeting the glucocorticoid-induced TNFR-related protein (GITR). Ragifilimab binds to and activates GITR on T cells, which stimulates the immune system to enhance its anti-tumor activity. Ragifilimab can be used for advanced or metastatic solid tumors research .
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Cat. No.: HY-P991180

Target:  

TNF Receptor

Research Areas:  

Cancer

TRX-518 is a humanized agylcosyl IgG1 anti-GITR mAb, , and is a GITR agonist. TRX-518 binds to the extracellular domain of human GITR, abrogates Treg-mediated suppression. TRX-518 increases effector T cell activation and pro-inflammatory cytokine production, reduces circulating and intratumor Treg frequencies. TRX-518 destabilizes Treg phenotype via Foxp3 downregulation and T-bet upregulation. TRX-518 can be used for the research of solid tumors[1][2][3].
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Cat. No.: HY-P991179

Target:  

TNF Receptor

Research Areas:  

Cancer

MK-4166 is a humanized IgG1 agonist monoclonal antibody targeting GITR. MK-4166 enhances the proliferation of both naïve and tumor-infiltrating T lymphocytes .
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Cat. No.: HY-159692
CAS No.: 2603457-08-3
Synonyms: IONIS-1063734
Target:  

FOXP

Research Areas:  

Cancer

AZD8701 (IONIS-1063734) is an antisense oligonucleotide targeting FOXP3 in regulatory T cells (Tregs), with a human IC50 of 65.2 nM. AZD8701 binds to intronic sites of all FOXP3 pre-mRNA isoforms and mediates dose-dependent FOXP3 knockdown via free uptake. AZD8701 can be used in cancer-related research .
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Cat. No.: HY-P990124
Anti-Mouse GITR Antibody (DTA-1) is a rat derived IgG2b monoclonal agonist antibody targeting mouse GITR. Anti-Mouse GITR Antibody (DTA-1) can activate T cells and B cells to enhance immune response. Anti-Mouse GITR Antibody (DTA-1) selectively enhances Th2 cell effector function through GITR signaling. Anti-Mouse GITR Antibody (DTA-1) may exacerbate allergic reactions. Anti-Mouse GITR Antibody (DTA-1) can be used for researches on cancer and allergic conditions such as colon cancer and allergic asthma. The recommed isotype control of Anti-Mouse GITR Antibody (DTA-1) is Rat IgG2b kappa, Isotype Control (HY-P990682) .
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Cat. No.: HY-P991178

Target:  

TNF Receptor

Research Areas:  

Cancer

BMS-986156 is a fully humanized IgG1 agonist monoclonal antibody agonist corticosteroid-induced tumor necrosis factor receptor-related protein (GITR). BMS-986156 binds to GITR and promotes activation of T effector cells and inactivates T regulatory cells. BMS-986156 is indicated for use in advanced solid tumor studies .
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Cat. No.: HY-P990240

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

Anti-Mouse GITR (LALA-PG) Antibody (DTA-1) is an anti-mouse GITR IgG2a monoclonal antibody. Anti-Mouse GITR (LALA-PG) Antibody (DTA-1) is a chimeric antibody of the original DTA-1 antibody (HY-P990124). Anti-Mouse GITR (LALA-PG) Antibody (DTA-1) contains the LALA-PG mutation region. Anti-Mouse GITR (LALA-PG) Antibody (DTA-1) can be used for research on cancer and allergic conditions. The recommed isotype control of Anti-Mouse GITR (LALA-PG) Antibody (DTA-1) is Mouse IgG2a kappa, Isotype Control (HY-P99978).
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Cat. No.: HY-P990241

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

Anti-Mouse GITR (D265A) Antibody (DTA-1) is an anti-mouse GITR IgG1 monoclonal antibody. Anti-Mouse GITR (D265A) Antibody (DTA-1) is a chimeric antibody of the original DTA-1 antibody (HY-P990124). Anti-Mouse GITR (D265A) Antibody (DTA-1) contains the D265A mutation region. Anti-Mouse GITR (D265A) Antibody (DTA-1) can be used for research on cancer and allergic conditions. The recommed isotype control of Anti-Mouse GITR (D265A) Antibody (DTA-1) is Mouse IgG1 kappa, Isotype Control (HY-P99977).
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Cat. No.: HY-P99876
CAS No.: 2102200-64-4
Synonyms: OMP-336B11

Target:  

Inhibitory Antibodies

Research Areas:  

Others

Efaprimermin alfa (OMP-336B11) is a human monoclonal antibody targeting TNFRSF18. Efaprimermin alfa is a GITR ligand-Fc fusion protein .
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Cat. No.: HY-P991404

Target:  

TNF Receptor

Research Areas:  

Cancer

AMG-228 is a human IgG1 monoclonal antibody (mAb) targeting TNFRSF18/GITR/CD357. AMG-228 can be used in advanced solid tumors research .
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Cat. No.: HY-RS14808
Research Areas:  

Others

TNFRSF18 Human Pre-designed siRNA Set A contains three designed siRNAs for TNFRSF18 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P991464

Target:  

TNF Receptor

Research Areas:  

Cancer

IBI37G5 is a human monoclonal antibody (mAb) targeting TNFRSF18/GITR/CD357. IBI37G5 has anti-tumor activity in MC38 and B16F10 mouse tumor models. IBI37G5 can be used in the study of cancer immunity .
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Cat. No.: HY-P990525

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

The Anti-TNFRSF18/GITR/CD357 Antibody is a CHO-expressed human antibody targeting TNFRSF18/GITR/CD357. The Anti-TNFRSF18/GITR/CD357 Antibody features a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-TNFRSF18/GITR/CD357 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
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Cat. No.: HY-P84896
Synonyms: AITR; gitr; CD357; gitr-D

Host:  

Mouse

Application:  

IHC-P, FC, ELISA

Reactivity:  

Human

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Cat. No.: HY-P84896A
Synonyms: AITR; gitr; CD357; gitr-D

Host:  

Mouse

Application:  

IHC-P, FC, ELISA

Reactivity:  

Human

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Cat. No.: HY-P992315
Synonyms: PTZ-522

Target:  

TNF Receptor

Research Areas:  

Cancer

ASP1951 (PTZ-522) is a monoclonal antibody that targets GITR and is a GITR agonist. ASP1951 can be used for the research of advanced solid tumours .
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Cat. No.: HY-P78137
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CD357; gitr; gitr-D; TNFRSF18; AITR
Species:  
Source:  
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Cat. No.: HY-P78640
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AITR; gitr; TNFRSF18; CD357
Species:  
Source:  
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Cat. No.: HY-P78716
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AITR; gitr; TNFRSF18; CD357
Species:  
Source:  
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Cat. No.: HY-P75164
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Tumor necrosis factor receptor superfamily member 18; CD357; TNFRSF18; AITR; gitr
Species:  
Source:  
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