FOXP

Forkhead box proteins (FOXPs) are transcription factors composed of FOXP1 (3p14.1), FOXP2 (7q31), FOXP3 (Xp11.23), and FOXP4 (6p21.1). They all possess a similar 110-amino acid DNA-binding domain, termed the winged helix/forkhead domain. FOXP1 regulates development of B cells, FOXP2 controls language development and FOXP4 mediates development of T cell. FOXP3, so called scurfin, is critically involved in differentiation and function of regulatory T cells or CD4+/CD25+ regulatory T (Treg) cells for cancer immunotherapy. FOXP proteins play important roles in the regulation of gene transcription in associated with immune function, carcinogenesis, differentiation and angiogenesis^[1][2].