Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression
- Mol Cancer. 2019 Dec 9;18(1):180. doi: 10.1186/s12943-019-1110-3.
Affiliations
- 1. Cancer Molecular Target Herbal Research Lab, College of Korean Medicine, Kyung Hee university, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 02447, Republic of Korea.
- 2. Department of Herbal Crop Research, Rural Development Administration, National Institute of Horticultural and Herbal Science, Eumseong, 27709, Republic of Korea.
- 3. Cancer Molecular Target Herbal Research Lab, College of Korean Medicine, Kyung Hee university, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 02447, Republic of Korea. [email protected].
PMID: 31815635
DOI: 10.1186/s12943-019-1110-3
Abstract
Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2, FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and Cancer progression, the underlying function of FOXP3 targeting CD4 + CD25+ regulatory T (Treg) cells and the dual roles of FOXP proteins as an oncogene or a tumor suppressor are unclear and controversial in cancers to date. Thus, the present review highlighted research history, dual roles of FOXP proteins as a tumor suppressor or an oncogene, their molecular networks with Other proteins and noncoding RNAs, cellular immunotherapy targeting FOXP3, and clinical implications in Cancer progression.
Keywords
Cellular immunotherapy; Clinical implications and cancer progression; FOXP proteins; Molecular networks; Noncoding RNAs.